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Although uncommon, severe depression with suicide ideation or attempts may be observed during treatment of MS with IFN-beta. This association should not discourage the use of this drug, but physicians need to be aware of this possible adverse event from IFN-beta.

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-Purpose: Pregnancy management poses an extra challenge to physicians and their multiple sclerosis (MS) patients. There are few papers reporting databases on the subject. Method: Brazilian database from nine MS clinical and research units, with complete data on 47 pregnant women (49 pregnancies). Results: Despite relatively high exposure to MS medications, no birth defects were reported. Low birth weight and prematurity were similar to those for developing countries. Three complications may have been associated with these medications, while three others were considered to be of purely obstetric nature. Conclusion: Our results confirm previous findings on lower relapse rate during pregnancy and add to the present literature informing on data related to drug exposure.Key wOrDS: multiple sclerosis, pregnancy, prematurity, low birth weight, obstetric complications, interferon beta, glatiramer acetate. gravidez e esclerose múltipla: resultados preliminares de base de dados Brasileira resumo -Propósito: O manejo da gravidez cria um desafio extra aos médicos e aos pacientes com esclerose múltipla (eM). existem poucos trabalhos relatando bases de dados neste tema. Método: Base de dados brasileira de nove centros clínicos e de pesquisa na eM, com dados completos de 47 mulheres grávidas (49 gestações). Resultados: Apesar da exposição a drogas para eM ter sido relativamente alta, não foram registradas malformações. Baixo peso e prematuridade foram semelhantes àqueles de países em desenvolvimento. Três complicações podem ter sido associadas a drogas, enquanto outras três foram consideradas como sendo de natureza puramente obstétrica. Conclusão: Nossos resultados confirmam os achados de menor taxa de surtos na gestação e adicionam dados relacionados a exposição a drogas, na literatura atual.PALAvrAS-chAve: esclerose múltipla, gravidez, prematuridade, baixo peso, complicações obstétricas, interferon beta, acetato de glatirâmer.

Multiple sclerosis (MS) management presently aims to reach a state of no (or minimal) evidence of disease activity. The development and commercialization of new drugs has led to a renewed interest in family planning, since patients with MS may face a future with reduced (or no) disease-related neurological disability. The advice of neurologists is often sought by patients who want to have children and need to know more about disease control at conception and during pregnancy and the puerperium. When MS is well controlled, the simple withdrawal of drugs for patients who intend to conceive is not an option. On the other hand, not all treatments presently recommended for MS are considered safe during conception, pregnancy and/or breastfeeding. The objective of the present study was to summarize the practical and evidence-based recommendations for family planning when our patients (women and men) have MS.Funding TEVA Pharmaceutical Brazil.