Objective: To determine the frequency and range of paraneoplastic neurologic disorders (PNDs) and neuronal antibodies in small cell lung carcinoma (SCLC).Methods: Two hundred sixty-four consecutive patients with biopsy-proven SCLC were recruited at the time of tumor diagnosis. All patients underwent full neurologic examination. Serum samples were taken prior to chemotherapy and analyzed for 15 neuronal antibodies. Thirty-eight healthy controls were analyzed in parallel.Results: PNDs were quite prevalent (n 5 24, 9.4%), most frequently Lambert-Eaton myasthenic syndrome (3.8%), sensory neuronopathy (1.9%), and limbic encephalitis (1.5%). Eighty-seven percent of all patients with PNDs had antibodies to SOX2 (62.5%), HuD (41.7%), or P/Q VGCC (50%), irrespective of their syndrome. Other neuronal antibodies were found at lower frequencies (GABAb receptor [12.5%] and N-type VGCC [20.8%]) or very rarely (GAD65, amphiphysin, Ri, CRMP5, Ma2, Yo, VGKC complex, CASPR2, LGI1, and NMDA receptor [all ,5%]). Conclusions:The spectrum of PNDs is broader and the frequency is higher than previously appreciated, and selected antibody tests (SOX2, HuD, VGCC) can help determine the presence of an SCLC. Neurology ® 2015;85:235-239 GLOSSARY HC 5 healthy control; LE 5 limbic encephalitis; LEMS 5 Lambert-Eaton myasthenic syndrome; PCD 5 paraneoplastic cerebellar degeneration; PEM 5 paraneoplastic encephalomyelitis; PND 5 paraneoplastic neurologic disorder; SCLC 5 small cell lung carcinoma; SN 5 sensory neuronopathy.A paraneoplastic neurologic disorder (PND) results from the indirect effect of a tumor on the nervous system or muscle without local invasion or metastasis. PNDs are often associated with antibodies that bind to proteins shared between the tumor and the nervous system.
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