This prospective British Ophthalmological Surveillance Unit (BOSU) study on dysthyroid optic neuropathy (DON) determines the incidence, presenting features and management throughout the UK. New cases were identified through the BOSU yellow card and an initial questionnaire and a subsequent 9-month follow-up questionnaire were posted out. From August 2015 to August 2016 DON was reported in 49 patients with 71 eyes affected, 22 patients had bilateral DON. The most common presenting symptom was blurred vision (83%) and the most common examination finding was upgaze restriction (85%). 85% of patients were initially treated with 3 days of either 1 g or 500 mg intravenous methyl prednisolone. We received 25 follow-up questionnaires (51% of the initial cohort) with 38 eyes treated for DON and 13 bilateral cases. The average steroid dose over 9 months was 4.5 g and 47% of patients had a surgical orbital decompression. The mean visual acuity gain after 9 months of follow-up for all patients was 0.25 LogMAR. The mean visual acuity gain after just medical therapy was 0.25 LogMAR and after both medical therapy and orbital decompression it was 0.24 LogMAR. In conclusion, the incidence of DON in the UK from this study is 0.75 per million population per annum. The majority of patients are treated with initial medical therapy and almost half of all patients subsequently went on to have an orbital decompression. With either medical therapy or medical and surgical therapy, vision can improve in patients with DON.
For end users to access various systems, services, and applications, multimedia data sharing is increasingly becoming an essential part of their daily lives. Cloud storage services in the real world frequently disclose data. In secure data transfer media, authenticity and copyright protection of multimedia content have always been a concern. As more people use the Internet and digital technologies, the issue has become more serious. Creating copyright protection, on the other hand, is more difficult and complicated. In proposed approach both Watermarking and Intermediary Re-encryption (PRE) approach used for productive mixed media content sharing. Watermarking is accustomed to concealing the data, for example, conceal privileged intel in computerized media like pictures. Data security is provided by encryption methods. In proposed work, secret key can be encoded utilizing encryption calculation with the assistance of key. The user's private key is then combined with the encrypted key information and can be embedded using LSB (Least Significant Bit) in the image or audio. The ECC Encryption algorithm can be used to encrypt an image or audio after secret information has been embedded. Finally, the embedded data verification process enables authorized users to extract the decryption key. When user information does not correspond with embedded information, illegal or unauthorized access can be identified. Furthermore, Block chain technology is used to safeguard these transaction details.
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