We describe here the most ambitious survey currently planned in the optical, the Large Synoptic Survey Telescope (LSST). The LSST design is driven by four main science themes: probing dark energy and dark matter, taking an inventory of the solar system, exploring the transient optical sky, and mapping the Milky Way. LSST will be a large, wide-field ground-based system designed to obtain repeated images covering the sky visible from Cerro Pachón in northern Chile. The telescope will have an 8.4 m (6.5 m effective) primary mirror, a 9.6 deg 2 field of view, a 3.2-gigapixel camera, and six filters (ugrizy) covering the wavelength range 320-1050 nm. The project is in the construction phase and will begin regular survey operations by 2022. About 90% of the observing time will be devoted to a deep-wide-fast survey mode that will uniformly observe a 18,000 deg 2 region about 800 times (summed over all six bands) during the anticipated 10 yr of operations and will yield a co-added map to r∼27.5. These data will result in databases including about 32 trillion observations of 20 billion galaxies and a similar number of stars, and they will serve the majority of the primary science programs. The remaining 10% of the observing time will be allocated to special projects such as Very Deep and Very Fast time domain surveys, whose details are currently under discussion. We illustrate how the LSST science drivers led to these choices of system parameters, and we describe the expected data products and their characteristics.

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Prepared by the LSST Science Collaborations, with contributions from the LSST Project. PrefaceMajor advances in our understanding of the Universe over the history of astronomy have often arisen from dramatic improvements in our ability to observe the sky to greater depth, in previously unexplored wavebands, with higher precision, or with improved spatial, spectral, or temporal resolution. Aided by rapid progress in information technology, current sky surveys are again changing the way we view and study the Universe, and the next-generation instruments, and the surveys that will be made with them, will maintain this revolutionary progress. Substantial progress in the important scientific problems of the next decade (determining the nature of dark energy and dark matter, studying the evolution of galaxies and the structure of our own Milky Way, opening up the time domain to discover faint variable objects, and mapping both the inner and outer Solar System) all require wide-field repeated deep imaging of the sky in optical bands.The wide-fast-deep science requirement leads to a single wide-field telescope and camera which can repeatedly survey the sky with deep short exposures. The Large Synoptic Survey Telescope (LSST), a dedicated telecope with an effective aperture of 6.7 meters and a field of view of 9.6 deg 2 , will make major contributions to all these scientific areas and more. It will carry out a survey of 20,000 deg 2 of the sky in six broad photometric bands, imaging each region of sky roughly 2000 times (1000 pairs of back-to-back 15-sec exposures) over a ten-year survey lifetime.The LSST project will deliver fully calibrated survey data to the United States scientific community and the public with no proprietary period. Near real-time alerts for transients will also be provided worldwide. A goal is worldwide participation in all data products. The survey will enable comprehensive exploration of the Solar System beyond the Kuiper Belt, new understanding of the structure of our Galaxy and that of the Local Group, and vast opportunities in cosmology and galaxy evolution using data for billions of distant galaxies. Since many of these science programs will involve the use of the world's largest non-proprietary database, a key goal is maximizing the usability of the data. Experience with previous surveys is that often their most exciting scientific results were unanticipated at the time that the survey was designed; we fully expect this to be the case for the LSST as well.The purpose of this Science Book is to examine and document in detail science goals, opportunities, and capabilities that will be provided by the LSST. The book addresses key questions that will be confronted by the LSST survey, and it poses new questions to be addressed by future study. It contains previously available material (including a number of White Papers submitted to the ASTRO2010 Decadal Survey) as well as new results from a year-long campaign of study and evaluation. This book does not attempt to be complete; there are many ...

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Positron emission tomography (PET) neuroimaging and behavioral assays in rodents are widely used in neuroscience. PET gives insights into the molecular processes of neuronal communication, and behavioral methods analyze the actions that are associated with such processes. These methods have not been directly integrated, because PET studies in animals have until now required general anesthesia to immobilize the subject, which precludes behavioral studies. We present a method for imaging awake, behaving rats with PET that allows the simultaneous study of behavior. Key components include the 'rat conscious animal PET' or RatCAP, a miniature portable PET scanner that is mounted on the rat's head, a mobility system that allows considerable freedom of movement, radiotracer administration techniques and methods for quantifying behavior and correlating the two data sets. The simultaneity of the PET and behavioral data provides a multidimensional tool for studying the functions of different brain regions and their molecular constituents.