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The highly regio- and enantioselective molybdenum-catalyzed allylic alkylation reaction has become a powerful synthetic tool during the past few years. This Account describes the achievements gained so far in the area, with special attention directed to the different chiral ligands that have been used for inducing chirality in the products, the range of allylic substrates and nucleophiles employed, mechanistic studies, and applications of the reaction in asymmetric syntheses.

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carboxylic acid esterscarboxylic acid esters (benzene compounds) Q 0530 -093Highly Stereo-and Regioselective Allylations Catalyzed by Mo-Pyridylamide Complexes: Electronic and Steric Effects of the Ligand.-The amide shown in entry D) containing electron-donating substituted pyridine rings is found to be an efficient ligand for the regio-and stereoselective allylation of the malonate (II). The use of ligands bearing electron-withdrawing substituted pyridine rings or alkyl substituted pyridine rings results in reduction of selectivity and yield.