Bu çalışmada, uzun bir reperfüzyon süresinden sonra iskemireperfüzyon hasarına karşı klopidogrel ve rivaroksaban karşılaştırıldı ve çeşitli dokular üzerindeki etkileri araştırıldı.Ça lış ma pla nı: Toplamda 40 Wistar sıçan çalışmaya dahil edildi ve rastgele dört gruba ayrıldı (grup başına n=10). Gruplar şu şekilde belirlendi: kontrol (Grup 1), sham (Grup 2), klopidogrel ön tedavisi (Grup 3) ve rivaroksaban ön tedavisi (Grup 4). Grup 2, 3 ve 4'te sıçanların arka bacaklarında iskemi (6 saat) ve reperfüzyon (8 saat) indüklendi. Oksidan (malondialdehit) ve antioksidanları (glutatyon, süperoksit dismutaz ve nitrik oksit) çalışmak için, deneklerin iskemik kas, kalp, böbrek, karaciğer ve plazma dokuları incelendi. Bul gu lar:Malondialdehit sham grubunda tüm dokularda kontrollere kıyasla anlamlı düzeyde yüksekti. Klopidogrel ve rivaroksaban ön tedavisi sham grubun kalp, iskemik kas, karaciğer ve kan dokularında malondialdehit düzeylerini anlamlı düzeyde düşürdü. Böbrek malondialdehit düzeyleri, yalnızca rivaroksaban ile azaldı. Grup 4'te, Grup 3'e kıyasla, iskemik kasta malondialdehit anlamlı düzeyde düşük bulundu (p<0.010). Böbrekte glutatyon düşüşü, sham grubuna kıyasla, yalnızca Grup 4 için anlamlıydı (p<0.050). Klopidogrel ve rivaroksaban ön tedavisi ile nitrik oksit düzeyleri, yalnızca kalp dokusunda sham grubuna kıyasla anlamlı düzeyde azaldı (sırasıyla p<0.001 ve p<0.050).So nuç:Çalışma sonuçları, rivaroksaban ve klopidogrelin kalp, iskemik kas, karaciğer ve kandaki iskemi-reperfüzyon hasarını azaltmada etkili olduğunu göstermektedir. Ayrıca rivaroksaban böbrekleri korur ve iskemik kas korumasında klopidogrelden üstündür.
Introduction: Naftidrofuryl and cilostazol are drugs with proven efficacy in the treatment of claudication in peripheral vascular disease. In this experimental study, we evaluated the effects of naftidrofuryl and cilostazol in ischemia-reperfusion (IR) injury on various tissues. Materials and Methods: 40 male albino Wistar rats (8-12 weeks old, 250-350 g.) are randomly divided into 4 groups: Control (Group 1), sham (group 2), cilostazol pre-treatment (group 3), naftidrofuryl pre-treatment (group 4). During 21 days placebo is given to group 2, 12 mg/kg/day cilostazol is given to group 3, 50 mg/kg/day naftidrofuryl is given to group 4 orally. Ischemia and reperfusion are induced at the lower hind limb in Groups 2, 3 and 4. Ischemic muscle, kidney, liver, heart, brain and blood samples are obtained. The total antioxidant capacity, oxidant levels and oxidative stress index are studied for each group. Results: Both drugs have protective effects of remote organ injury following IR. Systemic effects are similar to each other, both have protective effects of IR injury. It showed no statistical significance in the total antioxidant capacity. Total oxidant levels are significantly affected by cilostazol in the heart (p < 0.01) and by naftidrofuryl in the liver (p < 0.01). The effect on oxidative stress was only significant with cilostazol on the heart (p < 0.01). Conclusion: Cilostazol and naftidrofuryl had beneficial effects in all tissues against tissue damage caused by IR injury. In ischemic muscle, kidney and heart cilostazol had improved outcomes comparing to naftidrofuryl. Naftidrofuryl had benefits over cilostazol in liver tissue.
Achondroplasia is the most common cause of dwarfism with short stature, short body and disproportionate development. This rare genetic disease, which is 0.5-1.5 in 10000 live births, is autosomal dominant inheritance and is common in women. Deficiency of endochondral bone formation and normal periostal bone formation disorder are characteristic; patients have bone deformities and systemic anomalies. 1 Atlantoaxial dislocation (AAD) may concurrently exist in achondroplastic patients either de novo, following surgery (foramen magnum decompression) or due to odontoid abnormalities (os odontoideum). Anesthetic management of achondroplastic patients with coexisting AAD offers a complex proposition for anesthesiologists in view of the anatomical and physiological constraints and the possible multisystem involvement. 2 In this case report, we aimed to present general anesthesia management in the context of the literature in an achondroplasic patient who was operated due to cardiac tamponade developed after pericardial effusion. CASE REPORT Pericardiocentesis was planned due to cardiac tamponade for a 24-year-old female patient, who is 92 cm tall and weighing 28 kg, diagnosed with achondroplasia in the ASA IIIE physiological class according to the American Society of Anesthesiologists (ASA). She was being treated at the endocrinology clinic due to myxedema and her T4: 0.9, TSH>100, with normal complete blood and renal functions. As she experienced respiratory distress, her endocrinologist demanded a cardiology consultation. Her echocardiography showed an ejection fraction of 60%, central arterial pressure 50 mmHg, tricuspid insufficiency, and a pericardial fluid surrounding the whole hearth. Her computed tomography revealed a malignant pericardial effusion entirely surrounding the heart, which reached 28-30 mm. She had distention due to abdominal ascites and her Glasgow Coma Score (GKS) was 12 (E:3M:5V:4). She had no limited neck extension, her mentohyoid and mentothy
ÖZKonjenital kalp hastalığı (KKH) ile doğan çocukların cerrahisindeki başarılı sonuçlar, anestezi uygulamaları sırasında farklı kardiyak hastalığı olan bu çoçuklarla karşılaş-ma olasılığımızı arttırmıştır. Kardiyak anatomik defektleri palyatif ya da kısmi olarak düzeltilen bu hastaların kardiyovasküler ve pulmoner rezervleri genellikle sınırlıdır. Anestezi uygulamaları sırasında bu durum daha da belirginleşebilmektedir. Bu makalede, Fontan sirkülasyonlu 16 yaşında erkek hastada, sol kolestatoma ve sol timpanomastoidektomi ameliyatındaki genel anestezi deneyimimizi sunduk. Fontan sirkulasyonlu çocukların, ikincil ameliyat öncesinde görülebilecek sorunlar açısından preoperatif değerlendirilmeleri ayrıntılı yapılmalıdır. Ayrıca, ameliyat sıra-sında özellikle pulmoner akımın bozulmasına neden olacak faktörler açısından bu çocukların yakın takibi gerekmektedir.Anahtar kelimeler: Genel anestezi, konjenital kalp hastalığı, Fontan sirkulasyonu ABSTRACT Successful surgical outcomes in children with congenital heart disease has increased the possibility of encountering these children with various cardiac diseases during anesthetic practices. These patients whose cardiac anatomical defects are treated palliatively or partially have generally restricted cardiovascular and pulmonary reserves. During the anesthetic practices, this condition may become more prominent. In this research we have presented our experience in general anesthesia applied during left cholesteatoma and left tympanomastoidectomy surgery in a 16-year-old male patient with Fontan circulation. Preoperative evaluations of the children with Fontan circulation must be done in detail in case of possible problems which might be seen before second surgery. Furthermore, these children must be followed up closely regarding factors which may impair pulmonary flow during the surgery.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.