No abstract

No abstract

Identification of rare inherited variants associated with ASD and 16 new ASD risk genes d Inherited risk reveals both new biological pathways and shared PPI with known genes d We develop and validate a machine learning algorithm (ARC) to remove WGS artifacts d NR3C2 mutations define a novel syndromic form of ASD, which we model in zebrafish

Autoimmunity in Lewy body dementia Lewy body dementia (LBD) is a brain disease that leads to progressive decline in thinking, movement, and independent function. It results from the build-up of microscopic deposits called Lewy bodies, which develop from the aggregation of a misfolded protein called α-synuclein. Gate et al . observed immune cells known as T cells in the brains of LBD patients (see the Perspective by Krot and Rolls). Genomics analysis revealed that T cells traffic to the LBD brain and are associated with neuronal damage. When stimulated with α-synuclein, LBD patient T cells secrete an inflammatory protein known to damage neurons. These findings suggest an unexpected detrimental role of the immune system in LBD. —SMH