Objective
Assess vitamin D supplementation alone or with calcium alters adiposity measures.
Methods
Systematic search (1966-March 2014) of MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials for randomized clinical trials (RCTs) with >50 participants aged ≥18 years at baseline and at least 12 weeks of treatment. Primary end points were changes in weight, body mass index (BMI), or fat mass (FM).
Results
Of 953 trials identified, 26 RCTs (12:Vitamin D alone; 10: Vitamin D plus calcium versus calcium control; 4:Vitamin D plus calcium versus placebo) met the inclusion criteria; 42,430 participants (median duration: 12 months). Vitamin D supplementation alone versus placebo: no significant change in BMI (weighted mean difference (WMD): −0.06 kg/m2, 95% CI: −0.14,0.03), weight (WMD: −0.05 kg, 95% CI:−0.32,0.23) or FM (WMD: −0.43 kg, 95% CI: −1.69,0.84). Vitamin D plus calcium versus calcium control: no significant reduction in BMI (WMD: 0.02 kg/m2, 95% CI: −0.11, 0.14), weight (WMD: 0.12 kg, 95% CI: −0.24, 0.49), or FM (WMD: 0.12 kg, 95% CI: −0.22, 0.45); no significant heterogeneity.
Conclusions
Vitamin D showed no effect on adiposity measures in adults.
We report a case of thyroid storm precipitated by SARS-CoV-2 infection in an adolescent girl with history of Graves disease and dilated cardiomyopathy. This case highlights that SARS-CoV-2 infection can potentially trigger a thyrotoxicosis crisis and acute decompensated heart failure in a patient with underlying thyroid disease and myocardial dysfunction even in the absence of multisystem inflammatory syndrome in children. We systematically reviewed the thyrotoxicosis cases with SARS-CoV-2 infection and described its impact on pre-existing dilated cardiomyopathy.
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