A national collaborative study was conducted in Japan to evaluate the clinical course and the sequelae of patients with hydatidiform mole coexistent with twin live fetus (HMTF). Seventy-two cases of HMTF were diagnosed based on gross appearance and histopathological criteria. In 18 cases, the molar parts were cytogenetically confirmed to be of androgenetic origin (complete mole). The overall incidence of persistent trophoblastic tumour (PTT) in patients with HMTF was 30.6%, and it increased to 50.0% in the 18 patients with proven androgenetic complete mole coexistent with twin live fetus (CHMTF). Among these patients, the mean gestational age at termination of pregnancy or delivery in those who developed PTT (n = 9) and those who did not (n = 9) were 20.6 and 19.4 weeks respectively. The incidence of severe maternal complications was significantly higher in patients who subsequently developed PTT (P < 0.05). The rate of subsequent development of PTT in patients with CHMTF was found to be considerably higher than in a previous study of patients with single complete mole (50 and 12.5% respectively). However, since the risk of malignancy is unchanged with advancement of gestational age, continued pregnancy may be allowed in patients with HMTF provided that severe maternal complications are controlled and fetal karyotype and development are normal.
The nuclear localization of Y-box-binding protein-1 (YB-1) is known to be a poor prognostic factor in several human malignancies, including ovarian carcinoma. Following on from our basic study dealing with microarray analyses of YB-1-associated gene expression in ovarian cancer cells, we examined whether nuclear localization of YB-1 is associated with the expression of CXCR4, a vault protein named lung resistance-related vault protein (LRP/MVP), phosphorylated Akt (p-Akt) or P-glycoprotein (P-gp) in human ovarian carcinoma. Fiftythree surgically resected ovarian carcinomas treated with paclitaxel and carboplatin were examined immunohistochemically for nuclear YB-1 expression and intrinsic expression of p-Akt, P-gp, LRP/MVP and CXCR4. Nuclear expression of YB-1 demonstrated significant correlation with p-Akt, P-gp and LRP expression, but no relationship with CXCR4 expression. By multivariate analysis, only YB-1 nuclear expression and CXCR4 expression were independent prognostic factors with regard to overall survival. These results indicate that YB-1 nuclear expression and CXCR4 expression are important prognostic factors in ovarian carcinoma. (Cancer Sci 2007; 98: 1020-1026) Y -box-binding protein-1 (YB-1) has been identified as a transcription factor that binds to the promoter region of several genes involved in positive regulation of the cell cycle, such as proliferating cell nuclear antigen, DNA topoisomerase II α, and multidrug resistance 1 gene (MDR1) which is linked to classical multidrug resistant (MDR).(1-3) Nuclear expression of YB-1 has been reported to have a close relationship with MDR1/P-glycoprotein (P-gp) expression in several human malignancies.(4-7) Moreover, YB-1 has been reported to be a prognostic marker of breast cancer, (4) ovarian cancer, (6) lung cancer (7) and synovial sarcoma.These clinicopathological studies consistently supported the notion that the absence or presence of YB-1 within the nucleus plays a critical role in the acquisition of malignant characteristics, including global drug resistance. Sutherland et al. have also reported that YB-1 phosphorylation by Akt is required for the nuclear translocation of YB-1: (9) Akt is a signal transduction protein that plays an important role in inhibiting apoptosis, stimulating angiogenesis, and promoting tumor formation in a variety of human malignancies.(10) Taking these findings together, translocation of YB-1 into the nucleus would seem to be mediated through pleiotropic signaling pathways. Our recent study demonstrated that the nuclear translocation of YB-1 is in part stimulated through Akt activation, and also that YB-1 is involved in upregulation and downregulation of various genes including P-gp, lung resistance-related vault protein (LRP/MVP) and CXCR4 in human ovarian cancer cells. The lung resistance-related vault protein (LRP) has been identified as the major vault protein (MVP), which is the major component of vaults, of subcellular particles that have been implicated in transmembrane transport processes.(12) YB-1 also has been...
UAE along with the administration of MTX is effective in treating cervical ectopic pregnancy with vaginal bleeding while allowing the preservation of fertility.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.