Activity. -In an effort to find novel potent antifungal agents, a variety of tetrazoles such as (IX), (X), (XI), and (XII) (58 examples in all) are synthesized and evaluated for their antifungal activity. Some of these compounds, e.g.(IXb-d), (Xb,c), (XIa), and (XIIa) possess good antifungal activity against different fungal cultures. In general, introduction of an additional methyl group at C-3 in compounds (IX) and (X) results in significant improvements of antifungal activity. -(UPADHAYAYA, R. S.; JAIN, S.; SINHA, N.; KISHORE, N.; CHANDRA, R.; ARORA*, S. K.; Eur.
A new series of antimycobacterial agents 2a-j, 3a-d, 6b-f,j, and 7b,f was designed, synthesized and evaluated for antimycobacterial activity against different mycobacterium species i.e. M. tuberculosis, M. avium, and M. intracellulare in an agar dilution method. Some of these compounds (2e, 3a-d) were highly potent with in vitro activity against M. tuberculosis H 37 Rv and clinical isolates (sensitive strains), equivalent to that of Isoniazid.
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