Recommendations from national regulatory agencies for ongoing cancer trials during the COVID-19 pandemicthe Birmingham Environment for Academic Research local Cloud. 10 UKCCMP delivers meaningful real-time data to all UK cancer centres and clinicians to allow more personalised approaches to individual patient care and inform clinical decision making. This initiative will improve cancer care in the UK and beyond at this time of unprecedented global turmoil and reliance on health-care resources.We declare no other competing interests. We thank the oncologists, acute physicians, and health-care staff working tirelessly on the frontlines of the COVID-19 pandemic. The UK Coronavirus Monitoring Project team donated time and resources to support the project. The project was initially funded through the donation of time and resources from the supporters and advocates of the project. The University of Birmingham initiated this process, with the Pro-Vice-Chancellor dedicating the computational and human resources of the University's Centre for Computational Biology, the Institute of Translational Medicine, and scientists from the Institute of Cancer and Genomic Sciences. Other academic institutions dedicating time and staff to the project include the
BackgroundRecent studies have suggested that B-type Natriuretic Peptide (BNP) is an
important predictor of ischemia and death in patients with suspected acute
coronary syndrome. Increased levels of BNP are seen after episodes of myocardial
ischemia and may be related to future adverse events.ObjectivesTo determine the prognostic value of BNP for major cardiac events and to evaluate
its association with ischemic myocardial perfusion scintigraphy (MPS).MethodsThis study included retrospectively 125 patients admitted to the chest pain unit
between 2002 and 2006, who had their BNP levels measured on admission and
underwent CPM for risk stratification. BNP values were compared with the results
of the MPS. The chi-square test was used for qualitative variables and the Student
t test, for quantitative variables. Survival curves were adjusted using the
Kaplan-Meier method and analyzed by using Cox regression. The significance level
was 5%.ResultsThe mean age was 63.9 ± 13.8 years, and the male sex represented 51.2% of
the sample. Ischemia was found in 44% of the MPS. The mean BNP level was higher in
patients with ischemia compared to patients with non-ischemic MPS (188.3 ±
208.7 versus 131.8 ± 88.6; p = 0.003). A BNP level greater than 80 pg/mL
was the strongest predictor of ischemia on MPS (sensitivity = 60%, specificity =
70%, accuracy = 66%, PPV = 61%, NPV = 70%), and could predict medium-term
mortality (RR = 7.29, 95% CI: 0.90-58.6; p = 0.045) independently of the presence
of ischemia.ConclusionsBNP levels are associated with ischemic MPS findings and adverse prognosis in
patients presenting with acute chest pain to the emergency room, thus, providing
important prognostic information for an unfavorable clinical outcome.
Objetivo: Avaliar a incidência de neoplasias malignas do esôfago na população de Volta Redonda, através de um estudo retrospectivo em 10 anos nos registros de diagnósticos histopatológicos. Método: foram obtidos 10.000 registros, pertencentes ao acervo da disciplina de Patologia Geral do Curso de Odontologia do UniFOA, oriundos do extinto Hospital da Companhia Siderúrgica Nacional na cidade de Volta Redonda, Rio de Janeiro, Brasil, registrados no período compreendido entre os anos de 1990 a 2000. Foram selecionados os casos diagnosticados como de neoplasias malignas que apresentaram o esôfago como sítio primário. Neoplasias metastáticas não foram consideradas. Resultados: Foram encontrados 1280 casos diagnosticados como de neoplasias malignas no referido serviço. Dentre esses, 3,90% (n=50) apresentaram como sitio primário o esôfago. A idade variou de 42 a 76 anos, com média de 65,6 anos, com predominância na faixa etária entre 60 e 69 anos (n=29). Ocorreram 38 casos no gênero masculino (76%) e 12 no feminino (24%). Em relação ao diagnostico histopatológico, a maioria dos casos foi de carcinomas epidermóides (n=35, 70%), tendo sido encontrados 15 casos (30%) de adenocarcinomas. Conclusões: A incidência encontrada foi de 3,9%, com maior ocorrência na faixa etária entre 60 e 69 anos e no gênero masculino. O principal tipo histológico foi o Carcinoma epidermóide.
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