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We established a system to generate hiPSC-derived hepatobiliary organoids in vitro. To varying degrees, this model recapitulated several key aspects of hepatobiliary organogenesis. The hepatobiliary organoids displayed a series of hepatic and biliary functional attributes. This system does not rely on any exogenous cells or genetic manipulation.

The turbulence and flows at the plasma edge during the L–I–H, L–I–L and single-step L–H transitions have been measured directly using two reciprocating Langmuir probe systems at the outer midplane with several newly designed probe arrays in the EAST superconducting tokamak. The E × B velocity, turbulence level and turbulent Reynolds stress at ∼1 cm inside the separatrix ramp-up in the last ∼20 ms preceding the single-step L–H transition, but remain nearly constant near the separatrix, indicating an increase in the radial gradients at the plasma edge. The kinetic energy transfer rate from the edge turbulence to the E × B flows is significantly enhanced only in the last ∼10 ms and peaks just prior to the L–H transition. The E × B velocity measured inside the separatrix, which is typically in the electron diamagnetic drift direction in the L-mode, decays towards the ion diamagnetic drift direction in response to fluctuation suppression at the onset of the single-step L–H, L–I–L as well as L–I–H transitions. One important distinction between the L–I–H and the L–I–L transitions has been observed, with respect to the evolution of the edge pressure gradient and mean E × B flow during the I-phase. Both of them ramp up gradually during the L–I–H transition, but change little during the L–I–L transition, which may indicate that a gradual buildup of the edge pedestal and mean E × B flow during the I-phase leads to the final transition into the H-mode. In addition, the transition data in EAST strongly suggest that the divertor pumping capability is an important ingredient in determining the transition behaviour and power threshold.

Dedicated experiments for the scaling of divertor power footprint width have been performed in the ITER-relevant radio-frequency (RF)-heated H-mode scheme under the lower single null, double null and upper single null divertor configurations in the Experimental Advanced Superconducting Tokamak (EAST) under lithium wall coating conditioning. A strong inverse scaling of the edge localized mode (ELM)-averaged power fall-off width with the plasma current (equivalently the poloidal field) has been demonstrated for the attached type-III ELMy H-mode as by various heat flux diagnostics including the divertor Langmuir probes (LPs), infra-red (IR) thermograph and reciprocating LPs on the low-field side. The IR camera and divertor LP measurements show that , in good agreement with the multi-machine scaling trend during the inter-ELM phase between type-I ELMs or ELM-free enhanced Dα (EDA). H-mode. However, the magnitude is nearly doubled, which may be attributed to the different operation scenarios or heating schemes in EAST, i.e., dominated by electron heating. It is also shown that the type-III ELMs only broaden the power fall-off width slightly, and the ELM-averaged width is representative for the inter-ELM period. Furthermore, the inverse Ip (Bp) scaling appears to be independent of the divertor configurations in EAST. The divertor power footprint integral width, fall-off width and dissipation width derived from EAST IR camera measurements follow the relation, λint ≅ λq + 1.64S, yielding . Detailed analysis of these three characteristic widths was carried out to shed more light on their extrapolation to ITER.

A stationary edge-localized mode (ELM)-absent H-mode regime, with an electrostatic edge coherent mode (ECM) which resides in the pedestal region, has been achieved in the EAST tokamak recently. This regime allows the operation of a nearly fully noninductive long pulse (>15 s), exhibiting a relatively high pedestal and good global energy confinement with H 98,y2 near 1.2, and excellent impurity control. Furthermore, this regime is mostly obtained with a 4.6 GHz lower hybrid current drive (LHCD) or counter-current neutral beam injection (NBI), plus electron cyclotron resonance heating, and an extensive lithium wall coating. This stationary ELM-absent H-mode regime transits to a stationary small ELM H-mode regime, and upon additional heating power from the 2.45 GHz LHCD, an ion cyclotron resonant frequency or co-current NBI is applied (under 4.6 GHz LHCD heating background). A slight change of the plasma configuration also makes the small ELMs reappear. The experimental observations suggest that a long-pulse ELM-absent regime can be induced by the ECM, which exhibits strong electrostatic fluctuations and may provide a channel for continuous particle (especially impurities) and heat exhaust across the pedestal. The ECM exists in the collisionality of ν * e = 2.5-4 and the pressure gradient |∇P| = | dP dρ | = 100-200 (kPa), which is in good agreement with the previous simulation of GYRO. This ELM-absent H-mode regime with ECM may offer a suitable candidate for high-performance, steady-state H-mode operation in future fusion reactors.

Dedicated experiments focusing on the influence of lower hybrid waves (LHWs) on edge-localized modes (ELMs) were first performed during the 2012 experimental campaign of EAST, via modulating the input power of LHWs in the high-confinement-mode (H-mode) plasma mainly sustained by ion cyclotron resonant heating. Natural ELMs are effectively mitigated (ELM frequency increases, while its intensity decreases dramatically) as the LHW is applied, observed over a fairly wide range of plasma current or edge safety factor. By scanning the modulation frequency (fm) of LHW injected power in a target plasma dominated by the so-called small ELMs, we conclude that large ELMs with markedly larger amplitudes and lower frequencies are reproduced at low modulation frequencies (fm < 100 Hz). Analysis of the evolution of edge extreme ultraviolet radiation signals further indicates that plasma fluctuations at the pedestal region indistinctively respond to rapid modulation (fm ⩾ 100 Hz) of LHW injected power. This is proposed as the mechanism responsible for the observed fm dependence of the mitigation effect induced by LHWs on large ELMs. In addition, a critical threshold of LHW input power PLHW is estimated as , beyond which the impact of applied LHWs on ELM behaviours can be achieved. Finally, Langmuir probe measurements suggest that, rather than the concentration of free energy into a narrowband quasi-coherent precursor commonly observed growing until the ELM crash, the continuous development of broadband turbulence during the ELM-absent phase with the application of LHWs might contribute to the avoidance of ELM crashes. These results present new insights into existing experiments, and also provide some foundations and references for the next-step research about exploring in more depth and improving this new attractive method to effectively control the ELM-induced very large transient heat and particle flux.

The fast electron flux driven by Lower Hybrid Wave (LHW) in the scrape-off layer (SOL) in EAST is analyzed both theoretically and experimentally. The five bright belts flowing along the magnetic field lines in the SOL and hot spots at LHW guard limiters observed by charge coupled device and infrared cameras are attributed to the fast electron flux, which is directly measured by retarding field analyzers (RFA). The current carried by the fast electron flux, ranging from 400 to 6000 A/m 2 and in the direction opposite to the plasma current, is scanned along the radial direction from the limiter surface to the position about 25 mm beyond the limiter. The measured fast electron flux is attributed to the high parallel wave refractive index n jj components of LHW. According to the antenna structure and the LHW power absorbed by plasma, a broad parallel electric field spectrum of incident wave from the antennas is estimated. The radial distribution of LHW-driven current density is analyzed in SOL based on Landau damping of the LHW. The analytical results support the RFA measurements, showing a certain level of consistency. In addition, the deposition profile of the LHW power density in SOL is also calculated utilizing this simple model. This study provides some fundamental insight into the heating and current drive effects induced by LHW in SOL, and should also help to interpret the observations and related numerical analyses of the behaviors of bright belts and hot spots induced by LHW. V C 2015 AIP Publishing LLC.

The poloidal distribution of type-III edge localized modes in the Mega-Ampère spherical tokamak (MAST)