A chitosan-based magnetic nanocomposite was synthesized by an eco-friendly and simple procedure, and was characterized using scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction and Fourier transform infrared spectroscopy. It was then used for the efficient synthesis of tetrahydrobenzoxanthen-11-one derivatives via a one-pot three-component condensation of 2-naphthol, various aldehydes and dimedone in ethanol. The catalyst was recovered easily and reused several times without significant loss of catalytic activity.
An environmentally benign and clean biopolymer-based heterogeneous nanocatalyst was prepared and its properties and morphology were characterized using scanning electron microscopy (SEM), energydispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD). Then, its catalytic activity was investigated in two important organic reactions. In these reactions, efficient and selective syntheses of 1,2-disubstituted benzimidazole and 1,5-benzodiazepine derivatives were carried out using 1,2-diamines and aldehydes or ketones in the presence of a catalytic amount of magnetically recoverable chitosansupported iron oxide nanoparticles (Fe 3 O 4 /chitosan), as a biodegradable nanocomposite, in ethanol at ambient temperature in high yields. The Fe 3 O 4 /chitosan nanocatalyst can be recovered easily and reused without any significant loss of the catalytic activity.
A practical and green approach for the one-pot multicomponent synthesis of tetraheterocyclic benzimidazolo[2,3-b]quinazolinones has been described via the condensation of 2-aminobenzimidazole or 2-aminobenzothiazole, dimedone, and various aldehydes using Fe3O4@chitosan as an environmentally benign and reusable nanocomposite catalyst in good to excellent yields.
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