Background: A potential role of testosterone among sex hormones has been hypothesized in identifying sex-related differences in the clinical consequences of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Due to the high global prevalence of hypogonadism, the relationship between hypogonadism and SARS-CoV-2 infection outcomes deserves an in-depth study.Objective: The present study aimed to investigate the relationship of serum testosterone with other laboratory parameters on the prognosis of coronavirus disease-19 (COVID-19) in male patients with COVID-19 diagnosis. Materials and methods:This prospective cohort study included 358 male patients diagnosed with COVID-19 and 92 COVID-19 negative patients admitted to the urology outpatient clinics as a control group. The COVID-19 patients were divided into groups according to prognosis (mild-moderate and severe group), lung involvement in chest computed tomography (<50% and >50%), intensive care unit needs, and survival. Results:The measured serum total testosterone level of the COVID-19 patients group was found to be significantly lower than that of the control group (median, 140 ng/dl; range, 0.21-328, 322 ng/dl; range, median, 125-674, p < 0.001, respectively). The serum TT levels were statistically significantly lower in severe COVID-19 patients compared to mild-moderate COVID-19 patients (median, 85.1 ng/dl; range, 0.21-532, median, 315 ng/dl; range, 0.88-486, p < 0.001, respectively), in COVID-19 patients in need of intensive care compared to COVID-19 patients who did not need intensive care (median, 64.0 ng/dl; range, 0.21-337, median, 286 ng/dl; range, 0.88-532 p < 0.001, respectively), and in COVID-19 patients who died compared to survivors (median, 82.9 ng/dl; range, 2.63-165, median, 166 ng/dl; range, 0.21-532, p < 0.001, respectively).
To investigate the effectiveness of benign prostatic hyperplasia (BPH)-related lower urinary tract symptoms (LUTS), which occur as a natural result of aging and androgen exposure, in predicting disease prognosis in male patients diagnosed with COVID-19. Methods: The study was planned prospectively. The study included 63 male patients over 40 years of age diagnosed with COVID-19. The patients were diagnosed with COVID-19 based on the results of reverse transcription polymerase chain reaction tests of oropharyngeal and nasopharyngeal swabs obtained as per the World Health Organization guidelines. The presence of LUTS was assessed by the International Prostate Symptom Score (I-PSS), a subjective assessment, and the I-PSS was filled for the patients included in the study. The patients were divided into three groups based on their scores in the I-PSS survey: group 1: mild (0-7), group 2: moderate (8-19), and group 3: severe (20-35). The data of all three groups were statistically analyzed. Results: In the assessment performed between the groups, it was identified that for patients in group 3, the length of hospital stay was longer, intensive care requirement was more frequent, and their mortality rates were numerically higher. In the evaluation made regarding the time to intensive care admittance, this was identified to be the shortest in group 3. Conclusion: As a result of our study, we think that in patients with COVID-19, BPH-related LUTS can guide clinicians in predicting prognosis.
Objectives:The aim of the study was to evaluate the oxidative stress level in patients, diagnosed with H. pylori infection, using a novel marker (thiol/disulphide homeostasis) and to compare the level in infected individuals with that in healthy volunteers. Methods: A total of 60 patients diagnosed with gastritis, erosive gastritis or ulcer by endoscopy were included and biopsied. The 30 patients diagnosed with H. pylori and 30 healthy individuals were enrolled. Medical histories, physical examination results, body mass index (BMI), hemogram, free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), urea, creatinin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin, total cholesterol, triglycerides, high density lipoprotein (HDL), low density lipoprotein) LDL and thiol/disulphide levels obtained in the study groups were compared. Results: There was no significant difference between the total thiol, native thiol, disulphide/native thiol and dissulphide/total thiol ratios of the patient and control group. When the H. pylori patients were stratified by endoscopic evaluation as having mild (superficial gastritis or normal appearance) or severe (ulcer or erosive areas) symptoms, there were significant differences in disulphide, disulphide/native thiol, disulphide/total thiol and native thiol/total thiol levels. We also observed BMI and the total, native thiol levels of H. pylori patients were inversely related.( r: 0.562, p = 0.001; r: 0.0552, p = 0.002). Conclusions: Thiol/disulphide homeostasis is likely to differ with both duration and severity of H. pylori infection. Further investigations are needed to investigate the effect of H. pylori on oxidative stress.
Aim: The purpose of this study was to investigate MPV and RDW values in DTC patients. Background: Differentiated Thyroid Cancer (DTC) is subdivided into papillary, follicular and papillary micro thyroid cancers. Mean Platelet Volume (MPV) and red cell distribution width (RDW) are markers which have been investigated in many cancers, but no data are available for DTC. Objective: MPV and RDW values were assessed in 108 patients with DTC, consisting of 44 with Papillary Thyroid Cancer (PTC) (mean age 43±13.9 years), 34 with Papillary Micro Thyroid Cancer (PmTC) (mean age 43.1 ± 10.6), and 28 with Follicular Cancer (FC) (mean age 46.9±12.5), and 77 control subjects (mean age 47.5±5.9). Methods: The patient and control groups were matched in terms of age, and body mass index. All subjects were investigated using platelet and biochemical parameters. Results: Both MPV [(PTC, PmTC, and FC) (p=0.000, p=0.000 and p=0.001, respectively)] and RDW (PTC, PmTC, and FC) (p=0.02, p=0.04 and p=0.02, respectively)] values increased in patients with DTC compared to the controls. MPV values were significantly positively correlated with CRP (r=0.247; p=0.043), postoperative thyroglobulin (r=0.246; p=0.03), gamma glutamyl transferase (r=0.024; p=0.762), tumor size (r=0.209; p=0.047) and RDW (r=0.207; p=0.005). Age, gender, total cholesterol, and C-reactive protein were identified as independent predictors of MPV. Adjustment for other these factors produced no alteration in these relative risks at multiple regression analysis. Conclusion: Our results suggest that patients with DTC have higher MPV and RDW values than healthy controls. MPV may represent a good follow-up criterion in DTC patients because of its positive correlation with tumor size and thyroglobulin.
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