The existence of coincidence points and common fixed points for mappings satisfying certain contractive conditions, without appealing to continuity, in a cone metric space is established. These results generalize several well-known comparable results in the literature.

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ABSTRACT. We prove some common fixed point results for four mappings satisfying generalized weak contractive condition in partially ordered complete b-metric spaces. Our results extend and improve several comparable results in the existing literature

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Citrus Greening Disease (CGD) was critically reviewed with respect to its history, origin, symptomatology, host range, pathogenic association, identification and detection, transmission and management. It is evident that the citrus disease has emerged as a potential serious threat to citrus production in all the citrus growing countries of the world including Pakistan. It is has been proved that in Pakistan the greening disease is the major cause of citrus decline; hence it is necessary to formulate definite planning and strategies.

Background:Whether methylation of the microRNA (mir)-124-3 CpG island is of relevance for the clinical course of a solid cancer and whether it shows association with clinicopathology or survival of patients with renal cell cancer (RCC) is not known as yet.Methods:In a cross-sectional study, relative methylation of mir-124-3 was measured in 111 RCC samples and 77 paired normal appearing tissues using quantitative methyl-specific PCR. Results were statistically compared with tumour histology, clinicopathological parameters and disease recurrence.Results:We found tumour-specific hypermethylation of mir-124-3 in samples of RCCs with clear cell histology (ccRCC) compared with paired normal appearing tissues (P<0.0001). Methylation was significantly increased in tumours with state of advanced disease (P<0.0001). Higher relative methylation was associated with worse recurrence-free survival in both univariate (hazard ratio=9.37; P=0.0005) as well as bivariate Cox regression analyses considering age, sex, diameter of tumours and state of advanced disease, metastasis and lymph node metastases as covariates (hazard ratios=5.9–18.2; P-values of 0.0003–0.008).Conclusion:We identified mir-124-3 CpG islands (CGI) methylation as a relevant epigenetic mark for ccRCC thus underlining the need for functional studies of potentially affected signalling pathways in kidney tumour models. Methylation of mir-124-3 is suggested as an independent prognosticator for ccRCC.

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