Polycystic ovarian syndrome (PCOS) is the most common cause of anovulatory fertility problems in women of reproductive age, with a prevalence as high as 40% to 75%. There are different treatment modalities for increasing the chance of pregnancy in PCOS patients. Since most of the PCOS patients suffer from ovulatory problems, therapeutic efforts are focused mainly towards restoring normal ovulation. However, even after pharmacological interventions to ameliorate ovulatory irregularities, women with polycystic ovary are still at high risk of fetal loss. Thus, assisted reproductive techniques (ARTs) have become popular approaches which significantly increase the chances of successful pregnancy in these women, bypassing the conditions of PCOS. The present mini-review ‘pinpoints’ on the suitability of ARTs for PCOS patients who fail to ovulate following the conventional infertility treatment. The article also briefly explains how intracytoplasmic sperm injection (ICSI), the most effectiveART, correlates with better biological parameters, fertilization rate and better quality of embryos in PCOS women.
Controlled ovarian stimulation (COS) has been used during an assisted reproduction cycle to improve the success rate. The gonadotropins which are most frequently used during COS/ICSI cycles are r-FSH and r-HMG (FSH+LH). Over many years, outcomes achieved with using both gonadotropins during COS have been compared and the superiority of using both or only r-FSH is still a controversial topic that necessitates further studying. The aim of this research is to study the effectiveness of adding r-HMG to r-FSH on ICSI outcome in infertile patients who underwent COS. Fifty infertile couples were included who attended fertility clinic due to either female factor or male factor infertility and all of them were treated by ICSI and subjected to COS by r-FSH with or without r-HMG. ICSI outcome was assessed in the form of the total number of retrieved oocytes, FR, CR, embryo quality and chemical PR.The study showed that there was no significant difference between using both gonadotropins or FSH alone regarding the total number of oocytes produced, fertilization rate (FR), cleavage rate (CR), embryos number and quality except pregnancy rate (PR) which was lower with adding r-HMG 41.66% VS 50 % with r-FSH alone. We concluded that the combined use of r-HMG+r-FSH is effective as r-FSH alone in terms of oocytes' and embryos' quality while the effect on PR is still undetermined.
Polycystic ovary syndrome (PCOS) is one of the major causes of decreased fertility in young females. Multiple extra- and intra-ovarian factors which are worked together or separately are responsible for sub-fertility. However, still, ovulatory dysfunction is the cornerstone that occurs as a result of hormonal dysfunction and consequently affects oocytes' quality, embryonic development and finally, implantation failure with a significant number of females seek assisted reproduction for getting pregnancy.
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