In this study, we present a method for prediction of the drug-release profile based on the physical mechanisms that can intervene in drug release from a drug-carrier. The application presented here incorporates the effects of drug concentration and Reynolds number defining the circulating flow in the testing vein. The experimental data used relate to the release of diclofenac from samples of non-degradable polyurethane subjected to static and continuous flow. This case includes simultaneously three mechanisms: burst-release, diffusion and osmotic pressure, identified beforehand here as being able to contribute to the drug liberation. For this purpose, authors coded the Sequential Quadratic Programming Algorithm to solve the problem of non-linear optimization. The experimental data used to develop the mathematical model obtained from release studies carried out in water solution at 37 °C, for three concentrations of diclofenac and two water flow rates. We discuss the contribution of mechanisms and kinetics by considering two aforementioned parameters and, following that, we obtain the specific-model and compare the calculated results with the experimental results for the reserved cases. The results showed that drug percentage mostly affect the burst release, however flow rate has affected the osmotic release. In addition, release kinetics of all the mechanisms have increased by increasing the values of two considered parameters.
The MPBL is an effective technology in terms of heat flow transport capacity: 10 MW.m, [2],with high level adaptability. A bond graph model of such a system is proposed in this paper. The model is dynamic, qualitative, configurable and pays particular attention to the dynamic of the transient regime. It aims at being a tool dedicated to designing the different components of a MPBL. It is also used for a physical analysis of the system in different operating conditions.
This article is devoted to the dynamic study of a brazed plate heat exchanger (BPHE). First, is proposed an introduction to the industrial context of the current FUI THERMOFLUIDE project. A succinct presentation of the heat exchanger technology is proposed. Afterward, is given a state of the art about BPHEs modeling, heat transfer and pressure drop correlations. Then a detailed mathematical description of an original dynamic model is presented. The last section deals with a description of the experimental test rig and performed validation tests.
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