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Protein-protein interactions (PPI) control most of the biological processes in a living cell. In order to fully understand protein functions, a knowledge of protein-protein interactions is necessary. Prediction of PPI is challenging, especially when the three-dimensional structure of interacting partners is not known. Recently, a novel prediction method was proposed by exploiting physical interactions of constituent domains. We propose here a novel knowledge-based prediction method, namely PPI_SVM, which predicts interactions between two protein sequences by exploiting their domain information. We trained a two-class support vector machine on the benchmarking set of pairs of interacting proteins extracted from the Database of Interacting Proteins (DIP). The method considers all possible combinations of constituent domains between two protein sequences, unlike most of the existing approaches. Moreover, it deals with both single-domain proteins and multiUnauthenticated Download Date | 5/13/18 1:16 AM CELLULAR & MOLECULAR BIOLOGY LETTERS 265 domain proteins; therefore it can be applied to the whole proteome in highthroughput studies. Our machine learning classifier, following a brainstorming approach, achieves accuracy of 86%, with specificity of 95%, and sensitivity of 75%, which are better results than most previous methods that sacrifice recall values in order to boost the overall precision. Our method has on average better sensitivity combined with good selectivity on the benchmarking dataset. The PPI_SVM source code, train/test datasets and supplementary files are available freely in the public domain

In this work, a novel deep learning technique for the recognition of handwritten Bangla isolated compound character is presented and a new benchmark of recognition accuracy on the CMATERdb 3.1.3.3 dataset is reported. Greedy layer wise training of Deep Neural Network has helped to make significant strides in various pattern recognition problems. We employ layerwise training to Deep Convolutional Neural Networks (DCNN) in a supervised fashion and augment the training process with the RMSProp algorithm to achieve faster convergence. We compare results with those obtained from standard shallow learning methods with predefined features, as well as standard DCNNs. Supervised layerwise trained DCNNs are found to outperform standard shallow learning models such as Support Vector Machines as well as regular DCNNs of similar architecture by achieving error rate of 9.67% thereby setting a new benchmark on the CMATERdb 3.1.3.3 with recognition accuracy of 90.33%, representing an improvement of nearly 10%.

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