Gold(I)-catalyzed reactions of electron-poor
alkynes are still
a challenging process. A straightforward synthesis of phosphorus-based
heterocycles, namely, 2-phenyl 1H-isophosphinoline
2-oxides 1, is reported. The reaction used PPh3AuCl precatalyst in combination with triflic acid under microwave
activation and afforded isophosphinoline 2-oxides 1 in
moderate to quantitative yields through a fully regioselective 6-endo-dig
hydroarylation cyclization, paving the way toward an effective synthesis
of phosphorus heterocycles.
An efficient and simple approach of the synthesis of some spiro indeno[1,2-b]quinoxalines via a one-pot three-component reaction of 11H-indeno[1,2-b]quinoxalin-11-one, pyrazolone, and malononitrile in the presence of Na 2 CO 3 at 70 8C is reported. This reaction has shown to have high atom economy.
A simple and efficient procedure for the synthesis of 2-hydroxy-2-(5-hydroxy-1H-pyrazol-4-yl)-2H-indene-1,3-dione derivatives, proceeding via aldol condensation between ninhydrin and various 3-alkyl-1H-pyrazol-5-ols is described. The syntheses were carried out in ethanol at room temperature and proceeded with short reaction times to give the products with high yields.
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