Background Malocclusion is a common oral health problem in schoolchildren. Literature describing the prevalence of malocclusion varies substantially across China. Aim This study identified the epidemiological characteristics of malocclusion among Chinese schoolchildren from 1991 to 2018. Design Six English and Chinese electronic databases were searched through November 2018. The search was supplemented by hand searching to identify relevant surveys. The overall prevalence of malocclusion was estimated by a random‐effects meta‐analysis model, and variations in different groups were assessed by subgroup meta‐analysis. Results Thirty‐seven eligible articles describing 117 682 samples were investigated. The pooled national prevalence for malocclusion was 47.92% (95% CI: 58.6%‐71.9%). For the Angle classification, the overall prevalence rates were 30.07% (95% CI: 25.37%‐35.48%), 9.91% (95% CI: 7.41%‐13.79%), and 4.76% (95% CI: 3.85%‐6.54%) for Class I, Class II, and Class III malocclusion, respectively. A deep overbite (16.67%, 95% CI: 11.50%‐23.08%) was shown to be the most common trait of malocclusion. When stratified by sex, males had a slightly higher prevalence than females (RR = 1.04, 95% CI: 1.01‐1.06). More importantly, an ascending trend and substantial variations across the country were observed. Conclusions Our results confirmed that malocclusion has become a serious oral health problem in Chinese schoolchildren, highlighting the need for proactive interventions at an early age. Moreover, high‐quality epidemiological studies on malocclusion are still required.

Objective This study intends to assess the prevalence of temporomandibular disorders and its clinical signs in Chinese students. Materials and Methods Search strategies were performed in seven electronic databases, and the reference lists from potentially relevant studies were searched manually. Only observational studies that met the eligibility criteria were selected. A validated instrument was used to evaluate the quality of the included studies. A random‐effects model was used to calculate the pooled prevalence of temporomandibular disorders and its clinical signs. Results Twenty‐three articles that met the eligibility criteria were included in this review and meta‐analysis. The prevalence of temporomandibular disorders was 29.1% (95% confidence interval [CI], 23.7–35.1; n = 12,702), and a significant difference was observed between males and females. The most prevalent sign was temporomandibular joint sounds (17.4%; 95% CI, 13.8–20.6; n = 6,615) followed by abnormal jaw movement (12.3%; 95% CI, 9.1–16.7; n = 5,496) and pain (9.9%; 95% CI, 7.4–13; n = 4,552). Conclusions The overall prevalence of temporomandibular disorders in Chinese students was approximately 29.1%, and a statistically significant difference was observed between males and females. The most prevalent sign was temporomandibular joint sounds (17.4%), followed by abnormal jaw movement (12.3%) and pain (9.9%).

Several genetic polymorphisms have been shown to affect the activity of taxanes. The most common gene reportedly associated with these effects is ATP-binding cassette transporter B subfamily member 1 (ABCB1), also