Surgery is superior to endotherapy for long-term pain reduction in patients with painful obstructive chronic pancreatitis. Better selection of patients for endotherapy may be helpful in order to maximize results. Due to its low degree of invasiveness, however, endotherapy can be offered as a first-line treatment, with surgery being performed in case of failure and/or recurrence.

Pancreatic carcinoma is a condition with late diagnosis and one for which there is no effective screening method. One possible diagnostic approach of so-called early adenocarcinoma is the identification and systematic examination of individuals at risk for this condition. Between 1992 and 2005 we systematically observed 223 individuals diagnosed with chronic pancreatitis. In this 14-year period we performed classical biochemical tests, endoscopic ultrasound, CT scans and ERCP. We also asked about the number of cigarettes smoked per year and classified individuals consuming regularly more than 80 g of alcohol per day for 5 years for men and 50 g of alcohol per day for 5 years for women as having the alcoholic form of chronic pancreatitis. The remaining patients were classified according to the TIGARO classification. Alcohol-related etiology was detected in 73.1% of patients, 21.5% had the chronic obstructive form and only 5.4% were classified as idiopathic pancreatitis. Pancreatic carcinoma was detected in 13 patients with chronic pancreatitis (5.8%), 3 patients were diagnosed with gastric carcinoma and 1 with esophageal carcinoma. Pancreatic malignancy developed mainly in patients with the alcoholic form of pancreatitis (4.5%). In the 14-year period 11 subjects died, out of which 8 cases were related to pancreatic carcinoma. Pancreatic and extrapancreatic cancer localized in the gastrointestinal tract are serious complications of chronic nonhereditary pancreatitis. Systematic observation of patients with chronic pancreatitis must be performed with the aim of early diagnosis of pancreatic malignancies (but also including other types).

Comparison of these results with studies by other authors showed that for most of the monitored parameters there was agreement with respect to the proportions of different breeds within the populations of dogs in different geographical areas.

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BACKGROUND: The goal of our study was to evaluate our hitherto 4-year surgical treatment of liver malignancies. METHODS: Our team performed 43 liver resections from 1997 to 2000. Of these, 10 were primary tumours and 33 metastases. The most frequent indication for resection in our sample was for colorectal cancer - in total 27 patients. Metastatic pancreatic cancer or metastases of malignant melanoma account for rarer indications to surgery We considered CT arterioportography (CTAP) as the most significant preoperative examination from all available radiological methods. RESULTS Proper resection of the liver is possible even without special technical equipment. No patient between the ages of 22 - 82 years died in the 30-day postoperative period. Our postoperative morbidity was 18.6%. The most frequent complication was prolonged biliary secretion from drains. In our study, recurrent liver malignancies occurred most frequently within 6 months from the primary resection. CONCLUSION: Radical resection procedure may be facilitated for the greatest number of patients with primary or metastatic liver malignancies by the cohesive cooperation of a number of specialists