Aim: To determine the incidence of non-severe keratitis (NSK) and severe keratitis (SK) among wearers of current generation contact lenses. Methods: A 12 month, prospective, hospital based epidemiological study was conducted by examining all contact lens wearers presenting with a corneal infiltrate/ulcer to a hospital centre in Manchester. A clinical severity matrix was used to differentiate between NSK and SK, based on the severity of signs and symptoms. The size of the hospital catchment population and the wearing modalities (daily wear (DW) or extended wear (EW)) and lens types being used were estimated from relevant demographic and market data. Results: During the survey period, 80 and 38 patients presented with NSK and SK, respectively. The annual incidences (cases per 10 000 wearers) for each wearing modality and lens type were: DW rigid-NSK 5.7, SK 2.9; DW hydrogel daily disposable-NSK 9.1, SK 4.9; DW hydrogel (excluding daily disposable)-NSK 14.1, SK 6.4; DW silicone hydrogel-NSK 55.9, SK 0.0; EW rigid-NSK 0.0, SK 0.0; EW hydrogel-NSK 48.2, SK 96.4; EW silicone hydrogel-NSK 98.8, SK 19.8. The difference in SK between EW hydrogel and EW silicone hydrogel was significant (p = 0.04). Conclusions: A clinical severity matrix has considerable utility in assessing contact lens related keratitis. There is a significantly higher incidence of SK in wearers who sleep in contact lenses compared with those who only use lenses during the waking hours. Those who choose to sleep in lenses should be advised to wear silicone hydrogel lenses, which carry a five times decreased risk of SK for extended wear compared with hydrogel lenses.
Risk factors for the development of contact lens keratitis were identified that, although being of limited predictive value for individual patients, highlight general associations that may assist in the management of contact lens wearers. Such risk factors may also assist in the development of a more complete understanding of the etiology of contact-lens-associated CEIs.
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Overall, there is an eight times higher incidence of CIEs in wearers who sleep in contact lenses compared with wearers who use lenses only during the waking hours. For those who choose to routinely or intermittently sleep in soft contact lenses, silicone hydrogels are the lens of first choice because CIEs are less clinically severe with this lens type compared with hydrogel lenses. The rate of significant visual loss as a result of developing a CIE is low.
These data statistically validate the previously held anecdotal notion that CIEs which occur in the peripheral cornea are less clinically severe than those which occur in the central cornea. Consideration of the distribution of CIEs may facilitate a better understanding of the etiology of these events and can serve to alert practitioners as to their likely clinical presentation.
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