A post-synthetic strategy is reported that permits functionalization of Au(i)–bis NHCs via carbonate formation and synthesis of a potential multifunctional anticancer therapeutic.
Au(i) bis-N-heterocyclic carbenes (NHCs) functionalized using an amide linker were found to bind to human serum albumin (HSA) in covalent and non-covalent fashion. The solubility and in vitro anti-cancer activity of these new conjugates were studied.
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