In yeast, Hmo1p is important for communicating target of rapamycin (TOR) kinase activity to downstream targets. Results show that TOR kinase controls expression of the HMO1 gene and that an important component of this regulation is its direct association with the HMO1 gene. The implications are that TOR kinase may have more elaborate nuclear functions.
To meet targets on fuel poverty, energy efficiency and carbon emissions existing homes need to be more energy efficient. We report the results of a participatory action research project to explore the challenges associated with energy efficiency retrofit programmes and ways to better implement future schemes.Six focus groups were held with 48 participants from a range of energy efficiency roles. Data were analysed thematically using the research question "What are the challenges presented by implementing energy efficiency retrofit programmes".We identified four themes in the data: Funding mechanisms; Predicting performance; Installation; and People. Challenges include funding mechanisms for retrofit programmes resulting in insufficient time to plan, publicise, implement and evaluate a scheme and insufficient flexibility to specify the most appropriate intervention for individual homes. Site workers sometimes need to adapt retrofit designs because of insufficient detail from the designer and can equate quality of installation with quality of finish. Landlords and occupier behaviour can impact on the programme's success and there is a need for greater information on benefits for landlords and for energy behaviour change interventions run alongside retrofit programmes for occupiers. There is a need for outcome evaluations of retrofit schemes with the results shared with stakeholders.
Chewing lice, Geomydoecus and Thomomydoecus, coexist on pocket gophers, Thomomys spp. We investigated the spatial distribution of the 2 genera on their hosts and explored possible mechanisms of resource partitioning by chewing lice. Chewing lice appear to partition available host resources spatially, with Geomydoecus occurring primarily on the lateral and dorsal regions of the host, and Thomomydoecus occurring primarily on the lateral and ventral regions. Although spatial partitioning of the host habitat is evident, it does not appear to be explained by hair diameter. Spatial partitioning of the host's body could be the result of some other factor, possibly temperature or humidity gradients of the host's body.
The
regioselectivity of hydroxyl radical addition to arenes was
studied using a novel analytical method capable of trapping radicals
formed after the first elementary step of reaction, without alteration
of the product distributions by secondary oxidation processes. Product
analyses of these reactions indicate a preference for o- over p-substitution for electron donating groups,
with both favored over m-addition. The observed distributions
are qualitatively similar to those observed for the addition of other
carbon-centered radicals, although the magnitude of the regioselectivity
observed is greater for hydroxyl. The data, reproduced by high accuracy
CBS-QB3 computational methods, indicate that both polar and radical
stabilization effects play a role in the observed regioselectivities.
The application and potential limitations of the analytical method
used are discussed.
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