In response to the rapid spread of COVID‐19 at the start of the pandemic, governments introduced severe measures of home confinement and isolation of the population in an effort to prevent their health systems from collapsing. On March 14, with more than 4000 confirmed cases 1 , Spain began its nationwide lockdown which has extended for almost three months

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Granuloma annulare may be caused by multiple triggers. Among these are vaccinations, which have been described as an infrequent cause of granuloma annulare. The authors report the first case of generalized granuloma annulare associated with pneumococcal vaccination in a 57-year-old woman, who presented cutaneous lesions 12 days after vaccination.

Several skin lesions have been associated with COVID-19, some of them classically related to other microbiological agents. 1 Recently, positivity for SARS-CoV/SARS-CoV-2 virus spike protein has been reported by immunohistochemistry (IHC) in skin biopsies from patients with erythema multiforme-like lesions or chilblains associated with COVID-19. 2,3 Granuloma annulare (GA) can be triggered by different viruses such as the Epstein-Barr virus (EBV), HIV, and hepatitis B and C. 4 Previously, we reported one patient with localized GA triggered after a SARS-CoV-2 infection. 5 Additionally, immunohistochemical staining and reverse transcription polymerase chain reaction (RT-PCR) techniques for SARS-CoV-2 detection

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