This review highlights recent developments in nylon polymer synthesis techniques, novel monomer structures developed, and biomedical applications of nylon polymers.
Syntheses and Ca2+ release potentials of four dimeric analogs of adenophostin A (AdA) through activation of type 1 IP3R are reported. These analogs are full agonists of IP3R and are equipotent to AdA, the most potent agonist of IP3R.
We
report the synthesis of diblock poly-amido-saccharides (PASs)
by sequential addition of variably protected glucose and galactose
monomers via living anionic ring-opening polymerization. Diblock polymers
with varied polymer length, hydrophobic to hydrophilic ratio, and
stereochemistry of hydrophilic component were synthesized, characterized
by NMR, IR, and GPC. These amphiphilic polymers self-assemble in water
to form nanoparticles as determined by DLS, SEM, and cryo-TEM. Amphiphilic
polymers with glucose-PAS hydrophobic and galactose-PAS hydrophilic
blocks and degree of polymerization of 100 (100-EtGlc1-OHGal3diblock PAS) form
spherical nanostructures and are non-cytotoxic.
Anticoagulant therapeutics are a mainstay of modern surgery and of clotting disorder management such as venous thrombosis, yet performance and supply limitations exist for the most widely used agent -...
Polysaccharides are abundant in nature and employed in various biomedical applications ranging from scaffolds for tissue engineering to carriers for drug delivery systems. However, drawbacks such as tedious isolation protocols, contamination, batch-to-batch consistency, and lack of compositional control with regards to stereo-and regioselectivity impede the development and utility of polysaccharides, and thus mimetics are highly sought after. We report a synthetic strategy to regioselectively functionalize poly-amido-saccharides with sulfate or phosphate groups using post-polymerization modification reactions. Orthogonally protected β-lactam monomers, synthesized from D-glucal, undergo anionic ring-opening polymerization to yield polymers with degrees of polymerization of 12, 25, and 50. Regioselective deprotection followed by functionalization and global deprotection affords the sulfated and phosphorylated poly-amido-saccharides. The resulting anionic polymers are water soluble and non-cytotoxic and adopt helical conformations. This new methodology provides access to otherwise inaccessible functional polysaccharide mimetics for biomedical applications.
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