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Going to primary health care services for diagnosis increased the time before diagnosis of the disease was reached. The Tuberculosis Control Program clinic was more effective in diagnosis of tuberculosis, due to the training of the staff and to an organized process for receiving patients, including the availability of tests to support the diagnosis.

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Histoplasmosis, caused by the dimorphic environmental fungus Histoplasma capsulatum, is a major mycosis on the global stage. Acquisition of the fungus by mammalian hosts can be clinically silent or it can lead to life-threatening systemic disease, which can occur in immunologically intact or deficient hosts, albeit severe disease is more likely in the setting of compromised cellular immunity. H. capsulatum yeast cells are highly adapted to the mammalian host as they can effectively survive within intracellular niches in select phagocytic cells. Understanding the biological response by both the host and H. capsulatum will facilitate improved approaches to prevent and/or modify disease. This review presents our current understanding of the major pathogenic mechanisms involved in histoplasmosis.

Introduction:In order to control tuberculosis, the Brazilian Ministry of Health recommends the decentralization of control actions directed to the Primary Health Care, and there are few studies on the performance of the Tuberculosis Control Program in decentralized contexts. Objective: To evaluate the performance of Primary Health Care services in tuberculosis treatment. Methods: This is an evaluative study with cross-sectional approach conducted in 2011. Two hundred and thirty-nine health professionals from Primary Health Care units were interviewed using a structured instrument based on the evaluation reference of the health services quality (structure -process -results). The performance of these services was analyzed applying techniques of descriptive statistics, validation, and construction of indicators and by determining the reduced variable "Z". Results: The indicators "participation of professionals in tuberculosis patients' care" (structure) and "reference and counterreference" (process) had the best evaluations, whereas "professional training" (structure) and "external actions for tuberculosis control" (process) had the worst results. Conclusion: The decentralization of tuberculosis control actions has been taking place in a vertical manner in Primary Health Care. The challenge of controlling tuberculosis involves overcoming constraints related to the engagement, training, and turnover rates among health professionals, which is a coordination between services and monitoring of control actions in Primary Health Care.

When plants grow in close proximity basic resources such as light can become limiting. Under such conditions plants respond to anticipate and/or adapt to the light shortage, a process known as the shade avoidance syndrome (SAS). Following genetic screening using a shade-responsive luciferase reporter line (PHYB:LUC), we identified DRACULA2 (DRA2), which encodes an Arabidopsis homolog of mammalian nucleoporin 98, a component of the nuclear pore complex (NPC). DRA2, together with other nucleoporins, participates positively in the control of the hypocotyl elongation response to plant proximity, a role that can be considered dependent on the nucleocytoplasmic transport of macromolecules (i.e. is transport dependent). In addition, our results reveal a specific role for DRA2 in controlling shade-induced gene expression. We suggest that this novel regulatory role of DRA2 is transport independent and that it might rely on its dynamic localization within and outside of the NPC. These results provide mechanistic insights in to how SAS responses are rapidly established by light conditions. They also indicate that nucleoporins have an active role in plant signaling.

O vínculo na atenção à saúde: revisão sistematizada na literatura, Brasil (1998-2007)*Bond in health care: a systematic review of literature in Brazil (1998Brazil ( -2007 El vínculo en la atención a la salud: revisión sistematizada en la literatura, Brasil (1998Brasil ( -2007 ABSTRACT Objective:To review the Brazilian scientific literature on bond in health care. Methods: The review was limited to the period from 1998 to 2007. A literature search was conducted in the LILACS and SciELO databases using the following key words: primary health care, acceptance, tuberculosis (indexed), bond, adhesion, health, basic care, continuity, and abandon (not indexed). Initially 50 publications were selected and categorized. Results: The findings suggest a greater interest on the topic after 2004. There was a predominance of publications on primary health care in journals that value community health. Conclusions: Bond was found to be an important factor in primary health care and led to better understanding of the real problems of the population receiving care in those services. In addition, bond facilitated the interactions between clients and health care professionals. Key Words: Primary health care; Scientific and technical publications; Professional-patient relations. RESUMENEl objetivo del estudio fue levantar producciones científicas brasileñas que se relacionaban con la dimensión vínculo en la atención primaria a la salud. El estudio abarcó el período de 1998 a 2007, a partir de las bases de datos LILACS y SciELO por medio de las palabras clave: atención primaria a la salud, acogimiento, tuberculosis (indexados), vínculo, adhesión, salud, atención básica, longitudinal y abandono (no indexados). Fueron seleccionadas 50 producciones que posteriormente fueron categorizadas. Los hallazgos mostraron que hubo un interés mayor por la temática después del año de 2004, predominando publicaciones en periódicos que valorizan la salud colectiva y estudios que se sitúan en el nivel primario de atención. Se entiende que el vínculo es un factor importante para la atención a la salud y tiende a mejorar el conocimiento de los reales problemas de la población atendida por los servicios, además de facilitar la relación de los usuarios con los profesionales que los atienden. Palabras clave: Atención primaria a la salud; Publicaciones científicas y técnicas; Relaciones profesional-paciente.