We conclude that AMS(+) subjects exhibit a more severe and prolonged oxygen desaturation than do AMS(-) subjects starting from the beginning of altitude exposure, but the predictive power of Spo2 is accurate only for AMS(++).
Participants who developed HHS failed to activate cardiovascular reflexes that usually safeguard O availability to match the metabolic needs of the brain tissue. Since cerebral hypoxia was detected as an early phenomenon by Δ[HbO] and Δ[HHb] changes, NIRS measurement appears to be the most important parameter to monitor the onset of HHS.
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