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In this study, biosorption of cadmium by Cystoseria myricaas as brown algae was investigated. Heavy metals, such as cadmium Cd (II), which are often present in industrial wastewaters, are dangerous to the aquatic ecosystem and pose a risk to human health as well. The experiment was conducted under conditions of varying pH, temperature, sorbent dosage, metal concentration, and contact time. The number of experiments was calculated by software Minitab. The design package Minitab software, a statistical program package, was used for regression analysis of the data obtained and estimation of the coefficient of the regression equation. The optimum condition was calculated by response surface methodology (RSM). The optimum conditions for removal of cadmium ion were obtained by theoretical equations. The response surfaces plots and contour plots were drawn using MATLAB.