Properties of the flame retardant urea formaldehyde (UF) board made from saw dust fibers were investigated. Flame retardant chemicals that were evaluated include boric acid (BA) and borax (BX) which were incorporated with saw dust fibers to manufacture experimental panels. Three concentration levels, (0.5, 1, and 5%) of fire retardants and 10% urea formaldehyde resin based on oven dry fiber weight were used to manufacture experimental panels. Physical and mechanical properties including water absorption, modulus of rupture (MOR), and modulus of elasticity (MOE) were determined. The results showed that water absorption and bending strength decreased as the flame retardant increased. The highest concentration of (BA + BX) enhanced the fire retardant more than the lower ones. Scanning electron microscope and FTIR of composite panels were studied.
A novel class of 6-indolypyridine-3-carbonitrilile derivatives were synthesized and evaluated for antiproliferative activities to establish structure-activity relationship. The synthesis was carried out through one-pot multicomponent reaction of 3-acetylindole, aromatic aldehydes, ethyl cyanoacetate, and ammonium acetate in the presence of piperidine as a catalyst, using a microwave irradiation method or a traditional thermal method. This was followed by chlorination for compounds 13a–e and subsequent nucleophilic substitution of the chlorine group by ethylenediamine at C2 position of the pyridine ring. The antiproliferative activity of these new nicotinonitriles was evaluated against human ovarian adenocarcinoma (SK-OV-3), breast adenocarcinoma (MCF-7), and cervix adenocarcinoma (HeLa) cells. Among all compounds, 2-((2-aminoethyl)amino)-4-aryl-6-indolylnicotinonitriles series (15a, 15b, 15d, and 15e) exhibited higher antiproliferative activity cells with IC50 values of 4.1–13.4 μM.
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