We present results on the electroexcitation of the low mass resonances (1232)P 33 , N (1440)P 11 , N (1520)D 13 , and N (1535)S 11 in a wide range of Q 2 . The results were obtained in the comprehensive analysis of data from the Continuous Electron Beam Accelerator Facility (CEBAF) large acceptance spectrometer (CLAS) detector at the Thomas Jefferson National Accelerator Facility (JLab) on differential cross sections, longitudinally polarized beam asymmetries, and longitudinal target and beam-target asymmetries for π electroproduction off the proton. The data were analyzed using two conceptually different approaches-fixed-t dispersion relations and a unitary isobar model-allowing us to draw conclusions on the model sensitivity of the obtained electrocoupling amplitudes. The amplitudes for the (1232)P 33 show the importance of a meson-cloud contribution to quantitatively explain the magnetic dipole strength, as well as the electric and scalar quadrupole transitions. They do not show any tendency of approaching the pQCD regime for Q 2 6 GeV 2 . For the Roper resonance, N (1440)P 11 , the data provide strong evidence that this state is a predominantly radial excitation of a three-quark (3q) ground state. Measured in pion electroproduction, the transverse helicity amplitude for the N (1535)S 11 allowed us to obtain the branching ratios of this state to the πN and ηN channels via comparison with the results extracted from η electroproduction. The extensive CLAS data also enabled the extraction of the γ * p → N (1520)D 13 and N (1535)S 11 longitudinal helicity amplitudes with good precision. For the N (1535)S 11 , these results became a challenge for quark models and may be indicative of large meson-cloud contributions or of representations of this state that differ from a 3q excitation. The transverse amplitudes for the N (1520)D 13 clearly show the rapid changeover from helicity-3/2 dominance at the real photon point to helicity-1/2 dominance at Q 2 > 1 GeV 2 , confirming a long-standing prediction of the constituent quark model.

Measurement of two-and three-nucleon shortrange correlation probabilities in nuclei KS The ratios of inclusive electron scattering cross sections of 4 He, 12 C, and 56 Fe to 3 He have been measured at 1 < x B < 3. At Q 2 > 1:4 GeV 2 , the ratios exhibit two separate plateaus, at 1:5 < x B < 2 and at x B > 2:25. This pattern is predicted by models that include 2-and 3-nucleon short-range correlations (SRC). Relative to A 3, the per-nucleon probabilities of 3-nucleon SRC are 2.3, 3.1, and 4.4 times larger for A 4, 12, and 56. This is the first measurement of 3-nucleon SRC probabilities in nuclei.

During muscle regeneration, the mechanism integrating environmental cues at the chromatin of muscle progenitors is unknown. We show that inflammation-activated MKK6-p38 and insulin growth factor 1 (IGF1)-induced PI3K/AKT pathways converge on the chromatin of muscle genes to target distinct components of the muscle transcriptosome. p38 alpha/beta kinases recruit the SWI/SNF chromatin-remodeling complex; AKT1 and 2 promote the association of MyoD with p300 and PCAF acetyltransferases, via direct phosphorylation of p300. Pharmacological or genetic interference with either pathway led to partial assembly of discrete chromatin-bound complexes, which reflected two reversible and distinct cellular phenotypes. Remarkably, PI3K/AKT blockade was permissive for chromatin recruitment of MEF2-SWI/SNF complex, whose remodeling activity was compromised in the absence of MyoD and acetyltransferases. The functional interdependence between p38 and IGF1/PI3K/AKT pathways was further established by the evidence that blockade of AKT chromatin targets was sufficient to prevent the activation of the myogenic program triggered by deliberate activation of p38 signaling.

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A study of the P 11 (1440) The transition helicity amplitudes from the proton ground state to the P11(1440) and D13(1520) excited states (γvpN * electrocouplings) were determined from the analysis of nine independent onefold differential π + π − p electroproduction cross sections off a proton target, taken with CLAS at photon virtualities 0.25 GeV 2 < Q 2 < 0.60 GeV 2 . The phenomenological reaction model was employed for separation of the resonant and non-resonant contributions to the final state. The P11(1440) and D13(1520) electrocouplings were obtained from the resonant amplitudes parametrized within the framework of a unitarized Breit-Wigner ansatz. They are consistent with results obtained in the previous CLAS analyses of the π + n and π 0 p channels. The successful description of a large body of data in dominant meson-electroproduction channels off protons with the same γvpN * electrocouplings offers clear evidence for the reliable extraction of these fundamental quantities from meson-electroproduction data. This analysis also led to the determination of the long-awaited hadronic branching ratios for the D13(1520) decay into ∆π (24%-32%) and N ρ (8%-17%).

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In an exclusive measurement of the reaction gammad-->K(+)K(-)pn, a narrow peak that can be attributed to an exotic baryon with strangeness S=+1 is seen in the K(+)n invariant mass spectrum. The peak is at 1.542+/-0.005 GeV/c(2) with a measured width of 0.021 GeV/c(2) FWHM, which is largely determined by experimental mass resolution. The statistical significance of the peak is (5.2+/-0.6)sigma. The mass and width of the observed peak are consistent with recent reports of a narrow S=+1 baryon by other experimental groups.

We report the first results of the beam-spin asymmetry measured in the reaction e⃗p→epγ at a beam energy of 4.25 GeV. A large asymmetry with a sinφ modulation is observed, as predicted for the interference term of deeply virtual compton scattering (DVCS) and the Bethe-Heitler process. The amplitude of this modulation is α = 0.202±0.028. In leading-order and leading-twist perturbative QCD, the α is directly proportional to the imaginary part of the DVCS amplitude