Exceptional magnetic properties of magnetite, Fe3O4, nanoparticles make them one of the most intensively studied inorganic nanomaterials for biomedical applications. We report successful gram-scale syntheses, via hydrothermal route or controlled coprecipitation in an automated reactor, of colloidal Fe3O4 nanoparticles with sizes of 12.9 ± 5.9, 17.9 ± 4.4, and 19.8 ± 3.2 nm. To investigate structure–property relationships as a function of the synthetic procedure, we used multiple techniques to characterize the structure, phase composition, and magnetic behavior of these nanoparticles. For the iron oxide cores of these nanoparticles, powder X-ray diffraction and electron microscopy both confirm single-phase Fe3O4 composition. In addition to the core composition, the magnetic performance of nanoparticles in the 13–20 nm size range can be strongly influenced by the surface properties, which we analyzed by three complementary techniques. Raman scattering and X-ray photoelectron spectroscopy (XPS) measurements indicate overoxidation of nanoparticle surfaces, while transmission electron microscopy (TEM) shows no distinct core–shell structure. Considered together, Raman, XPS, and TEM observations suggest that our nanoparticles have a gradually varying nonstoichiometric Fe3O4+δ composition, which could be attributed to the formation of Fe3O4–γ-Fe2O3 solid solutions at their outermost surface. Detailed analyses by TEM reveal that the hydrothermally produced samples include single-domain nanocrystals coexisting with defective twinned and dimer nanoparticles, which form as a result of oriented-attachment crystal growth. All our nanoparticles exhibit superparamagnetic-like behavior with a characteristic blocking temperature above room temperature. We attribute the estimated saturation magnetization values up to 84.01 ± 0.25 emu/g at 300 K to the relatively large size of the nanoparticles (13–20 nm) coupled with the syntheses under elevated temperature; alternative explanations, such as surface-mediated effects, are not supported by our spectroscopy or microscopy measurements. For these colloids, the heating efficiency in magnetic hyperthermia correlates with their saturation magnetization, making them appealing for therapeutic and other biomedical applications that rely on high-performance nanoparticle-mediated hyperthermia.
In this work, we develop a field-effect transistor with a two-dimensional channel made of a single graphene layer to achieve label-free detection of DNA hybridization down to attomolar concentration, while being able to discriminate a single nucleotide polymorphism (SNP). The SNP-level target specificity is achieved by immobilization of probe DNA on the graphene surface through a pyrene-derivative heterobifunctional linker. Biorecognition events result in a positive gate voltage shift of the graphene charge neutrality point. The graphene transistor biosensor displays a sensitivity of 24 mV/dec with a detection limit of 25 aM: the lowest target DNA concentration for which the sensor can discriminate between a perfect-match target sequence and SNP-containing one.
Ultralong single-crystalline CoP nanowires were grown on porous Co foam via a vapor–solid reaction method and used for overall electrochemical water splitting in alkaline solution.
Carbon dots have demonstrated great potential as luminescent nanoparticles in bioapplications. Although such nanoparticles appear to exhibit low toxicity compared to other metal luminescent nanomaterials, today we know that the toxicity of carbon dots (C-dots) strongly depends on the protocol of fabrication. In this work, aqueous fluorescent C-dots have been synthesized from cinnamon, red chilli, turmeric and black pepper, by a one-pot green hydrothermal method. The synthesized C-dots were firstly characterized by means of UV–vis, fluorescence, Fourier transform infrared and Raman spectroscopy, dynamic light scattering and transmission electron microscopy. The optical performance showed an outstanding ability for imaging purposes, with quantum yields up to 43.6%. Thus, the cytotoxicity of the above mentioned spice-derived C-dots was evaluated in vitro in human glioblastoma cells (LN-229 cancer cell line) and in human kidney cells (HK-2 non-cancerous cell line). Bioimaging and viability studies were performed with different C-dot concentrations from 0.1 to 2 mg·mL−1, exhibiting a higher uptake of C-dots in the cancer cultures compared to the non-cancerous cells. Results showed that the spice-derived C-dots inhibited cell viability dose-dependently after a 24 h incubation period, displaying a higher toxicity in LN-229, than in HK-2 cells. As a control, C-dots synthesized from citric acid did not show any significant toxicity in either cancerous or non-cancerous cells, implying that the tumour cell growth inhibition properties observed in the spice-derived C-dots can be attributed to the starting material employed for their fabrication. These results evidence that functional groups in the surface of the C-dots might be responsible for the selective cytotoxicity, as suggested by the presence of piperine in the surface of black pepper C-dots analysed by ESI-QTOF-MS.
A series of colloidal M x Fe 3−x O 4 (M = Mn, Co, Ni; x = 0−1) nanoparticles with diameters ranging from 6.8 to 11.6 nm was synthesized by hydrothermal reaction in aqueous medium at low temperature (200 °C). Energy-dispersive X-ray microanalysis and inductively coupled plasma spectrometry confirm that the actual elemental compositions agree well with the nominal ones. The structural properties of the obtained nanoparticles were investigated by powder X-ray diffraction, Raman spectroscopy, Mossbauer spectroscopy, X-ray and neutron pair distribution function analysis, and electron microscopy. The results demonstrate that our synthesis technique leads to the formation of chemically uniform single-phase solid solution nanoparticles with cubic spinel structure, confirming intrinsic doping. The local structure of the Fe 3 O 4 NPs is distorted with respect to the cubic inverse-spinel structure, while chemical substitution of Fe by Mn or Ni partially eliminates the local distortions. Magnetic studies showed that, in comparison to nondoped Fe 3 O 4 , the saturation magnetization (M s ) of M x Fe 3−x O 4 (M = Mn, Ni) decreases with increasing dopant concentration, while Co-doped samples showed similar M s . On the other hand, whereas Mn-and Ni-doped nanoparticles exhibit superparamagnetic behavior at room temperature, ferrimagnetism emerges for Co x Fe 3−x O 4 nanoparticles, which can be tuned by the level of Co doping.
Ultrafine molybdenum sulfide (MoS) nanocrystals are grown on a porous cobalt (Co) foam current collector by atomic layer deposition (ALD) using molybdenum hexacarbonyl and hydrogen sulfide as precursors. When used to catalyze the oxygen evolution reaction (OER), the optimal Co@MoS electrode, even with a MoS loading as small as 0.06 mg cm, exhibits a large cathodic shift of ca. 200 mV in the onset potential (the potential at which the current density is 5 mA cm), a low overpotential of only 270 mV to attain an anodic current density of 10 mA cm, much smaller charge transfer resistance and substantially improved long-term stability at both low and high current densities, with respect to the bare Co foam electrode, showing substantial promise for use as an efficient, low-cost and durable anode in water electrolyzers.
In general, ilmenite FeTiO 3 is synthesized by solid-state reaction at very high pressure and high temperature. Synthesis of FeTiO 3 is not an easy task as the Fe 2 þ ions are not stable. Therefore, it is really challenging to prepare this material. In this work nano-ilmenite FeTiO 3 was synthesized by the sol-gel method. Structural, optical and magnetic characterizations were performed. The bandgap of FeTiO 3 was determined to be 2.8 eV showing FeTiO 3 as suitable wide bandgap material for technological applications. The FeTiO 3 nanoparticles exhibit weak ferromagnetic properties at and below room temperature. The Né el temperature was observed to be around 52 K.
Ten years have passed since the beginning of graphene research. In this period we have witnessed breakthroughs both in fundamental and applied research. However, the development of graphene devices for mass production has not yet reached the same level of progress. The architecture of graphene field-effect transistors (FET) has not significantly changed, and the integration of devices at the wafer scale has generally not been sought. Currently, whenever an electrolyte-gated FET (EGFET) is used, an external, cumbersome, out-of-plane gate electrode is required. Here, an alternative architecture for graphene EGFET is presented. In this architecture, source, drain, and gate are in the same plane, eliminating the need for an external gate electrode and the use of an additional reservoir to confine the electrolyte inside the transistor active zone. This planar structure with an integrated gate allows for wafer-scale fabrication of high-performance graphene EGFETs, with carrier mobility up to 1800 cm(2) V(-1) s(-1). As a proof-of principle, a chemical sensor was achieved. It is shown that the sensor can discriminate between saline solutions of different concentrations. The proposed architecture will facilitate the mass production of graphene sensors, materializing the potential of previous achievements in fundamental and applied graphene research.
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