Objective: To determine the independent contribution of androgenic sex hormones beyond visceral adipose tissue (VAT) on metabolic risk. Design and Methods: A cross-sectional evaluation of 66 (36 white and 30 black) premenopausal overweight/obese women using multiple regression analyses to determine the independent effects of sex hormone-binding globulin (SHBG), total testosterone (TT), and free testosterone using the free androgen index (FAI) on metabolic variables above VAT. Results: SHBG contributed to the variance in insulin (P ¼ 0.003), insulin resistance using HOMA-IR (P ¼ 0.006), and high-density lipoprotein cholesterol 2 (P ¼ 0.029). TT contributed to the variance in systolic and diastolic blood pressure (P < 0.001), total cholesterol (P ¼ 0.003), low-density lipoprotein cholesterol (P ¼ 0.003), and apolipoprotein B (P ¼ 0.004). FAI contributed to the variance in the greatest number of metabolic variables beyond VAT. There was also a significant race-FAI interaction for fasting glucose (P ¼ 0.013). A Pearson's correlation coefficient showed a significant relationship between FAI and glucose in white women (r ¼ 0.48, P ¼ 0.003) while showing no relationship in black women (r ¼ À0.01, P ¼ 0.941). Conclusions: Our study showed that androgenic sex steroids contributed significantly to the variance in metabolic variables associated with health risk. However, they do not provide sufficient information relevant to glucose status in black women.
Aims and Method. The present study examined the relationship between the metabolic risk profile (MRP) and total testosterone (TT) and free testosterone using the free androgen index (FAI) and sex hormone binding globulin (SHBG) in 36 Caucasian American (CA) and 30 African-American (AA) women volunteering for a weight loss study.
Results. After controlling for age, significant relationships were found between TT and diastolic blood pressure (P = .004 and P = .015 in CA and AA women, resp.). Additionally, total cholesterol (P = .003), low density lipoprotein cholesterol (P = .004), apolipoprotein B (P = .006), and the total cholesterol/high density lipoprotein cholesterol (P = .027) were significantly related to TT in AA women only.
In CA women, similar measures of glucose/insulin status related to FAI, were also related to SHBG. In both CA and AA women, SHBG was related to waist (P = .031 and P = .022 resp.).
Conclusion. Our findings showed racial disparities in the relationship between the sex steroid milieu and the MRP in overweight/obese CA and AA women.
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