Because of the increased incidence and prevalence, ulcerative colitis (UC) has become a global health issue in the world. Current therapies for UC are not totally effective which result in persistent and recurrent symptom of many patients. Lactobacillus with anti-inflammatory effects might be beneficial to the prevention or treatment for UC. Here, we examined the ameliorative effects of the metabolites of Lactobacillus fermentum F-B9-1 (MLF) in Caco-2 cells and dextran sodium sulfate (DSS)-induced UC model mice. MLF displayed intestinal barrier-protective activities in Caco-2 cells by increasing the expression of Occludin and ZO-1. They also showed anti-inflammatory potential in interleukin (IL)-1β and IL-6. In order to further examine the in vivo anti-inflammatory effect of MLF, the MLF was gavaged in the DSS-induced UC model mice. The intragastric administration of MLF effectively alleviated colitis symptoms of weight loss, diarrhea, colon shortening, and histopathological scores, protected intestinal barrier function by increasing Occludin and ZO-1, and attenuated colonic and systemic inflammation by suppressing production of IL-1β and IL-6. Finally, the use of MLF remodeled the diversity of the gut microbiota and increased the number of beneficial microorganisms. Overall, the results demonstrated that MLF relieved DSS-induced UC in mice. And MLF might be an effective therapy method to UC in the clinic in the future.
Gingivitis is a kind of oral disease caused by local inflammation. The periodontal diseases with the highest clinical incidence in adults are chronic gingivitis and periodontitis. However, most of the antibiotics used in clinical treatment of periodontal disease are those that produce bacterial resistance and interfere with the ecological balance of oral flora. Research shows that honeysuckle, forsythia, coptis and other heat-clearing and detoxifying traditional Chinese medicine can assist periodontal basic treatment has a good effect on periodontitis and can be applied for a long time. In order to study the anti-inflammatory effects of common Chinese medicines on gingivitis, 27 kinds of Chinese medicines were selected and extracted by enzymolysis and boiling method. The antibacterial effects on bacteria and fungi were detected by the AGAR plate Oxford cup method. The best antibacterial effects of rhubarb, honeysuckle, coptis chinensis, galla chinensis, liquorice, forsythia, and clove were screened, and their inhibitory effects on inflammatory factors were further detected by human gingival epithelial cells. The results showed that rhubarb, honeysuckle, coptis chinensis, galla chinensis, glycyrrhiza, forsythia suspensa, and clove could inhibit inflammatory factors.
Pulmonary disease has long been a major problem in the world medical community. Common drugs for the treatment of pulmonary diseases, such as albuterol and pirfenidone, have many side effects in clinical use. Therefore, it is of great significance to find new safe drugs to solve the clinical disadvantages of Western medicine. At present, increasing numbers of medicinal plant extracts have been testified to be effective in clinical trials of pulmonary diseases. The unique physiological structure of the lung provides convenience for aerosol inhalation therapy, and avoids adverse reactions caused by oral and injection administration. This review article aims to introduce the application of some medicinal plants in the treatment of lung diseases. The combination of medicinal plants and aerosol inhalation drug delivery system can improve the targeting, safety and effectiveness of drugs. With the development of technology and experience accumulation, aerosol inhalation treatment of medicinal plants brings hope for the treatment of pulmonary diseases.
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