A series of pyrrole-indolin-2-ones were synthesized, and their inhibition profile for Aurora kinases was studied. The potent compound 33 with phenylsulfonamido at the C-5 position and a carboxyethyl group at the C-3' position selectively inhibited Aurora A over Aurora B with IC50 values of 12 and 156 nM, respectively. Replacement of the carboxyl group with an amino group led to compound 47, which retained the activity for Aurora B and lost activity for Aurora A (IC50=2.19 microM). Computation modeling was used to address the different inhibition profiles of 33 and 47. Compounds 47 and 36 (the ethyl ester analogue of 33) inhibited the proliferation of HCT-116 and HT-29 cells and suppressed levels of the phosphorylated substrates of Aurora A and Aurora B in the Western blots.
This work aims to clarify the effect of magnetic graphene oxide (GO) reorientation in a polymer matrix on the ionic conduction and methanol barrier properties of nanocomposite membrane electrolytes. Magnetic iron oxide (Fe 3 O 4 ) nanoparticles were prepared and dispersed on GO nanosheets (GO-Fe 3 O 4 ). The magnetic GO-Fe 3 O 4 was imbedded into a quaternized polyvinyl alcohol (QPVA) matrix and crosslinked (CL-) with glutaraldehyde (GA) to obtain a polymeric nanocomposite. A magnetic field was applied in the through-plane direction during the drying and film formation steps. The CL-QPVA/GO-Fe 3 O 4 nanocomposite membranes were doped with an alkali to obtain hydroxide-conducting electrolytes for direct methanol alkaline fuel cell (DMAFC) applications. The magnetic field-reoriented CL-QPVA/GO-Fe 3 O 4 electrolyte demonstrated higher conductivity and lower methanol permeability than the unoriented CL-QPVA/GO-Fe 3 O 4 membrane or the CL-QPVA film. The reoriented CL-QPVA/GO-Fe 3 O 4 nanocomposite was used as the electrolyte in a DMAFC and resulted in a maximum power density of 55.4 mW·cm −2 at 60 • C, which is 73.7% higher than that of the composite without the magnetic field treatment (31.9 mW·cm −2 ). In contrast, the DMAFC using the CL-QPVA electrolyte generated only 22.4 mW·cm −2 . This research proved the surprising benefits of magnetic-field-assisted orientation of GO-Fe 3 O 4 in facilitating the ion conduction of a polymeric electrolyte.
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