IntroductionMultimorbidity and polypharmacy are major risk factors for potentially inappropriate prescribing (eg, overprescribing and underprescribing), and systematic medication reviews are complex and time consuming. In this trial, the investigators aim to determine if a systematic software-based medication review improves medication appropriateness more than standard care in older, multimorbid patients with polypharmacy.Methods and analysisOptimising PharmacoTherapy In the multimorbid elderly in primary CAre is a cluster randomised controlled trial that will include outpatients from the Swiss primary care setting, aged ≥65 years with ≥three chronic medical conditions and concurrent use of ≥five chronic medications. Patients treated by the same general practitioner (GP) constitute a cluster, and clusters are randomised 1:1 to either a standard care sham intervention, in which the GP discusses with the patient if the medication list is complete, or a systematic medication review intervention based on the use of the 'Systematic Tool to Reduce Inappropriate Prescribing'-Assistant (STRIPA). STRIPA is a web-based clinical decision support system that helps customise medication reviews. It is based on the validated ‘Screening Tool of Older Person’s Prescriptions’ (STOPP) and ‘Screening Tool to Alert doctors to Right Treatment’ (START) criteria to detect potentially inappropriate prescribing. The trial’s follow-up period is 12 months. Outcomes will be assessed at baseline, 6 and 12 months. The primary endpoint is medication appropriateness, as measured jointly by the change in the Medication Appropriateness Index (MAI) and Assessment of Underutilisation (AOU). Secondary endpoints include the degree of polypharmacy, overprescribing and underprescribing, the number of falls and fractures, quality of life, the amount of formal and informal care received by patients, survival, patients’ quality adjusted life years, patients’ medical costs, cost-effectiveness of the intervention, percentage of recommendations accepted by GPs, percentage of recommendation rejected by GPs and patients’ willingness to have medications deprescribed.Ethics and disseminationThe ethics committee of the canton of Bern in Switzerland approved the trial protocol. The results of this trial will be published in a peer-reviewed journal.Main fundingSwiss National Science Foundation, National Research Programme (NRP 74) ‘Smarter Healthcare’.Trial registration numbersClinicaltrials.gov (NCT03724539), KOFAM (Swiss national portal) (SNCTP000003060), Universal Trial Number (U1111-1226-8013).
This study examined patient and caregiver's perception regarding pervasive healthcare technology using five focus groups and a 31-item questionnaire. To further develop an understanding of the benefits and functionalities that prospective patients deem as either desirable, undesirable, inadequate or in need of further development the study was categorized under 7 main headings: Personal Profile; Benefits; Adoption; Acceptance; Risks; Security, Privacy and Trust; (use of) Cell Phone. This study was completed as part of the European Union BRAVEHEALTH project, aimed at the support of cardiac patients in everyday life using in vivo monitoring and diagnosis, thereby enabling the patient to be more proactive in heath management. Most participants felt that there is a great future for this technology and showed positive response in regards to the potential benefits but are (at present) not willing to adopt the system due to concerns over reliability, like security, privacy and trust.
Physical inactivity is increasingly becoming part of today’s lifestyle, leading to a rapid increase in the incidence of diseases including cardiovascular disease, diabetes, and obesity. These chronic diseases are, for the most part, preventable by adopting a healthy lifestyle including regular physical activity. To help people maintain appropriate physical activity levels, researchers are developing interventions based on concepts from social science and ICT solutions. In this line, we investigate virtual communities (or social networks) as a candidate solution to support people in achieving their daily physical activity goals. This study observes and explores the differences between using the virtual community and a physical activity monitoring system on the physical activity level. We designed an exploratory study with a duration of 9 weeks in which an intervention group used a virtual community with a physical activity monitoring system and a control group used only a physical activity monitoring system. The results of this exploratory study demonstrate that using virtual communities may motivate and support people in their daily physical activity; in particular, we observed a decrease in the use of the system later than was observed in previous studies. Future investigations are needed to confirm the effect of the virtual community on physical activity.
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