No abstract

R-FC significantly improved the outcome of patients with previously treated CLL.

The addition of cladribine to the standard induction regimen is associated with increased rate of complete remission and improved survival of adult patients with AML.

The aim of the study was to investigate whether interleukin-10 (IL-10) genetic polymorphisms influence this cytokine production as well as the incidence and outcome of diffuse large B-cell lymphoma (DLBCL). The frequency of IL-10 -1082G allele was found to be higher in 199 patients with DLBCL as compared with 112 control subjects (0.47 versus 0.39, P ‫؍‬ .043). Increased serum levels of IL-10 were associated with adverse prognostic factors and poor DLBCL outcome. The frequencies of IL-10 -819T and IL-10 -592A alleles were lower in patients with elevated IL-10 serum levels (0.155 versus 0.32, P ‫؍‬ .14).