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Key Points Deep clonal responses to chemotherapy are associated with improved renal and overall outcomes in patients with light chain deposition disease. Deep clonal responses should be targeted, even in patients with advanced chronic kidney disease from light chain deposition disease.

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The discovery that bradyarrhythmias heralded terminal cardiac decompensation in most patients with severe cardiac AL amyloidosis supports a study of prophylactic pacemaker insertion in this patient population.