To assess the effects of oophorectomy on body weight, 60 adult female rats were divided into two groups (30 in each group): Group A -- young rats; Group B -- adult rats. The animals of each group were divided into three subgroups: Subgroup 1 (n= 6) -- control; Subgroup 2 (n= 6) -- laparotomy; Subgroup 3 (n= 18) -- bilateral oophorectomy. The weight of the animals was weekly assessed during 13 weeks and the results were compared by Student t test, with significance for p<0.05. The oophorectomized rats presented higher weight gain than those of the other groups. The difference was significant after eleven weeks, in Group A, and nine weeks, in Group B, until the end of the experiment. In the present work, bilateral oophorectomy in rats was related to higher body weight, independent on the age of the animals.
Purpose
The spleen is relevant in blood purification, hematopoiesis, metabolism, and
immune response to antigens, in addition to the storage and control on the
release of metals and amino acids. Its functions concerning reproduction
characteristics are still unknown. The objective was to study the influence
of splenectomies on reproduction.
Methods
This study analyzed 25 mice couples, distributed into five groups: group 1 –
control, no surgery: group 2 – control, submitted to laparotomy and
laparorrhaphy only; group 3 – splenectomy in male mice; group 4 –
splenectomy in female mice; group 5 – splenectomy in male and female mice.
The animals were studied as regards the number of gestations and offspring
generated in each gestation.
Results
A decrease in both the number of gestations and the number of offspring was
verified in the male mice that had received a splenectomy when coupled with
normal female mice. It is important to emphasize lower reproduction level
when paired asplenic males with normal females, otherwise, the couples in
which both mice had been splenectomized did not present change in the
reproduction pattern.
Conclusions
A reduction in the number of pregnancies and litters occurs in mice couples
when the male mice were previously splenectomized.
Introduction and importance
A wandering spleen is characterized by excessive splenic mobility due to the laxity of its ligaments, which leads to spleen migration and its long mobile vascular pedicle is liable to torsion. The purpose of this paper was to present a wandering splenomegaly reduction after splenic detorsion and splenopexy.
Case presentation
A 14-year-old boy presented a symptomatic visible pelvic wandering splenomegaly with torsion of the splenic pedicle. He was submitted to laparotomy, detorsion of the spleen, and splenopexy to the left diaphragm and surrounded peritoneum. The patient had an uneventful follow-up and was discharged from the hospital on the second postoperative day. All laboratory exams went to normal. The size of the spleen reduced from the 22 × 16 × 13 cm before the treatment to 14 × 12 × 10 cm after the surgical procedure.
Clinical discussion
The most relevant aspect of this communication is the reduction of the huge splenomegaly to a normal size spleen after detorsion of the splenic vessels and splenopexy to the left diaphragm. Reduction of the splenic size is well-known after distal splenorenal shunt, but this is the first publication of a spontaneous splenic size reduction after treating a congestive wandering splenomegaly by detorsion of the spleen pedicle.
Conclusion
Ectopic congestive splenomegaly due to the splenic pedicle rotation is adequately treated by splenic detorsion and splenopexy in its proper subdiaphragmatic site, which reduces the splenic size to normal.
hematological and biochemical values of splenic effluent blood are higher than those found in peripheral blood in the presence of schistosomal splenomegaly. However, the splenic blood effluent is not sufficient to raise the blood levels found after splenectomy.
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