The neurophysiological mechanism underlying sedation, especially in school-aged children, remains largely unknown. The recently emerged resting-state functional magnetic resonance imaging (rsfMRI) technique, capable of delineating brain's functional interaction pattern among distributed brain areas, proves to be a unique and powerful tool to study sedation-induced brain reorganization. Based on a relatively large school-aged children population (n=28, 10.3±2.6 years, range 7-15 years) and leveraging rsfMRI and graph theoretical analysis, this study aims to delineate sedation-induced changes in brain's information transferring property from a whole brain system perspective. Our results show a global deterioration in brain's efficiency properties (p=0.0085 and 0.0018, for global and local efficiency, respectively) with a locally graded distribution featuring significant disruptions of key consciousness-related regions. Moreover, our results also indicate a redistribution of brain's information-processing hubs characterized by a right and posterior shift as consistent with the reduced level of consciousness during sedation. Overall, our findings inform a sedation-induced functional reorganization pattern in school-aged children that greatly improve our understanding of sedation's effect in children and may potentially serve as reference for future sedation-related experimental studies and clinical applications.
The migration characteristics of iron ions in laterite in water can reflected by change characteristics of iron ion concentration in water solution. Its migration ability depends on itself features of laterite and the effect of external environment. The results show that, the migration ability of iron ion in laterite were weakened with increasing of compaction energy and extending of immersion times, were strengthed with increasing of moisture content and temperature. The effect of compaction energy is least, the effect of temperature is maximum, the effect of moisture content is between them. Its migration process is that iron ion of adsorption in laterite particles surface were dissolved and migrated into process of the water solution. Its migration mechanism can explained from water environmental balance and temperature balance and ion concentration balance. The results changed the migration characteristics of iron ion in laterite at different influencing factors.
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