We created the INSPPIRE 2 (INternational Study Group of Pediatric Pancreatitis: In search for a cuRE) Cohort to study the risk factors, natural history and outcomes of pediatric acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). Patient and physician questionnaires collect information on demographics, clinical history, family and social history, and disease outcomes. Health-related quality of life, depression, and anxiety are measured with validated questionnaires. Information entered on paper questionnaires is transferred into a database managed by Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer’s (CPDPC) Coordinating and Data Management Center (CDMC). Biosamples are collected for DNA isolation and analysis of most common pancreatitis-associated genes.
Twenty-two sites (18 in United States, 2 in Canada, and 1 each in Israel and Australia) are participating in the INSPPIRE 2 study. These sites have enrolled 211 subjects into the INSPPIRE 2 database toward our goal to recruit over 800 patients in 2 years. The INSPPIRE 2 Cohort Study is an extension of the INSPPIRE Cohort Study with a larger and more diverse patient population. Our goals have expanded to include evaluating risk factors for CP, its sequelae, and psychosocial factors associated with pediatric ARP and CP.
Introduction: Abdominal pain is common and is associated with high disease burden and health care costs in pediatric acute recurrent and chronic pancreatitis (ARP/CP). Despite the strong central component of pain in ARP/CP and the efficacy of psychological therapies for other centralized pain syndromes, no studies have evaluated psychological pain interventions in children with ARP/CP. The current trial seeks to 1) evaluate the
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