Introduction: Colorectal cancer (CRC) is the most incident in Spain, according to Spanish Network of Cancer Registries (REDECAN) and is the second cause of death by cancer in Spain. Although the OS in metastatic setting has increased to 24-30 months, the 5-year OS continues to be less than 12%. The first and second line of treatment are well defined; however, there are few therapeutic options for those patients who have progressed to these standard therapies. After progression to the second line of treatment, the only therapeutic options with approved specific indication are Regorafenib and Trifluridine and Tipiracil. Trifluridine and Tipiracil has shown its efficacy in two randomized clinical trials comparing Trifluridine and Tipiracil versus placebo: a Phase II and a Phase III study (RECOURSE). In the previous Phase II study, the mOS was 9.0 months in the group treated with Trifluridine and Tipiracil, compared to 6.6 months in the placebo group. In the RECOURSE study, among patients treated with Trifluridine and Tipiracil mPFS was 2 months versus 1.7 months among those treated with placebo, and mOS was 10,5 with Trifluridine and Tipiracil vs 7,6 with placebo. We described the clinical characteristic of patients treated with Trifluridine and Tipiracil in seven hospitals from Madrid; identifying and analyzing clinical factors associated with long-term response. Methods: We collected retrospectively the clinical data of 98 patients who had received treatment with Trifluridine and Tipiracil until January 2018 in seven different hospitals in Madrid. Results: The mean age at first use of Trifluridine and Tipiracil was 666 9.45 years, 57.5% were men and 42.3% were women, most of them in good performance status P À 268 Advanced colorectal cancer and risk factors for survival
This program was developed as a universal model of typical devices for protecting electrical networks with insulated neutral. Imitation experiments are executed by the design of working operating and emergency modes. It has been established as in real-world conditions with unselective wearing-outs of protecting as possible. IntroductionPower systems are exposed to damage and abnormal operated modes. The main reasons of damage are: the violations of isolation current parts, overvoltage, mechanical damage, damages of wires and supports electricity transmission line, connecting with their unsatisfactory state, ice surface and etc. [1].For protecting power systems from damage and abnormal modes of work are used the different types of relay protection and automation. However, in the process of exploitation power grid there are many situations, leading to the non-selective protection of operation work. The most common situations include the fluctuations of voltage in the mining industry where powerful electro-consumers are: fans, lifting options, main conveyors and and so forth. For example: undervoltage of network leads to failure of protection devices, in emergency operation of work on the protected accession, as the voltage increases -to the unselective disconnecting as emergency operation out of the protected accession. Uncontrolled changes of the protected networks in the parameters lead to decrease to efficiency of the protection means.Calculation of settings and characteristics of operation for the grid of enterprise is producing at the moment of their planning, from the calculation of their maximal power. The most cases of operating electric chart, energy supplies of entered and developing enterprises again (the period of exit enterprise to full capacity could be reached for a few years) considerably differs from designed. While the map of setpoints remains unchanging, so becomes the main reason of unselective operation to protecting devices. Especially, it is characteristically for the enterprises of mining industry, particularly for coal and ore mines.The repair modes, also modes of reserve feed from substations are different from power require the additional groups of setpoints operetion, that remains without of attention and as the results of unselective actions at defensive devices.In addition, considerable influence on efficiency of protecting exert capabilities and settings of protecting electrical network. Maintainly in the expended case of sourcing electricity and electrical transmission line with equally spaced settings of demand specifications and time-varying parameters of defensive electrical network include in general the power source of electrical main with distributed constants capacity as usual induction motor and elements of devices, formation an integral part of protection. Simulation Modes Of Relay Protection Devices In Networks With Insulated Neutral EAI Endorsed Transactions on Energy Web and Information Technology Research ArticleKeywords: the network with the insulated neutral, ...
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