The reactions of polyfluorochalcones with o aminothiophenol in methanol in the presence of HCl afford polyfluorine substituted 2,3 dihydrobenzo[b] [1,5]thiazepines. In some cases, the cyclization is accompanied by fluorine substitution in the perfluorophenyl ring. Probably, the formation of thiazepines proceeds through the Michael thia adduct. The Zn salt of o amino thiophenol reacts with chalcones in DMF exclusively via fluorine substitution.
Reactions of Polyfluorinated Chalcones with o-Aminobenzenethiol and Its ZincSalts. -HCl-catalyzed reactions of polyfluorochalcones with o-aminothiophenol afford polyfluorine-substituted 2,3-dihydrobenzothiazepines. In some cases, the cyclization proceeds along with fluorine substitution in the perfluorophenyl ring. The reaction of the zinc salt of o-aminothiophenol with chalcones proceeds exclusively via fluorine substitution. -(SHMUILOVICH, K. S.; ORLOVA*, N. A.; BEREGOVAYA, I. V.; SHELKOVNIKOV, V. V.; Russ.
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