With improved outcomes following treatment of breast cancer, chronic toxicities including breast cancer related lymphedema (BCRL), gain increased significance with limited evidence-based guidelines present. This review attempts to summarize data addressing these concerns and provides recommendations based on currently published data. Substantial differences exist in rates of BCRL reported in the literature ranging from less than 5% to 65% based on locoregional therapy. Based on recent data, early diagnosis of BCRL appears critical and requires careful attention to patient risk factors and the use of newer diagnostic tools. Initial treatment with decongestive lymphatic therapy/compressive stockings can provide significant improvement in patient symptoms and volume reduction of edematous extremities. At this time, consensus recommendations for disease classification, diagnostic testing and treatment are still lacking. Awareness of the frequency of this toxicity is now important as more accurate clinical aids have become accessible to diagnose the condition at an earlier stage allowing timely intervention providing the opportunity for treatment strategies to be more effective.
Despite widespread dissemination of cancer to multiple organs, muscle metastasis remains a rare occurrence. Limiting factors in this regard include, among others, repetitive muscle contraction, increased lactic acid, and decreased pH as well as protease metabolism. With the approval of hospital's research committee, a 10-yr review of histopathologic and imaging studies of patients diagnosed as having muscle metastasis was attempted. A review of the literature dealing with this phenomenon was also initiated. The review of the literature with reference to muscle metastasis highlighted its rare occurrence, which in turn correlated with our own 40-yr clinical experience (M.M.L.). As a potential target, muscle tissue remains an "infrequent soil" for metastasis because of its unique mechanical and metabolic qualities.
A 33-yr-old man presented with a 4-yr history of neck pain. Previous work-ups, including planar radiographs and magnetic resonance imaging, were determined as "normal" by six previous consultants. In a subsequent in-office evaluation by a physiatrist, a vertebral osteoid osteoma or carotid artery angiitis was clinically suspected. A bone scan of the cervical spine was consistent with a the presence of an of osteoid osteoma. Thereafter, repeat magnetic resonance imaging confused the issue by suggesting the presence osteomyelitis involving the C3-C4 facet joint. Spiral cervical spine computed tomography with digital reconstruction once again demonstrated the presence of an osteoblastoma. The patient was subsequently referred to a spinal surgeon for biopsy and resection, which confirmed the presence of an osteoblastoma. Although benign cervical neoplasms presenting as neck pain occur most often in a pediatric population, at any age, the differential diagnosis of intractable neck pain should include the possibility of a primary osseous or metastatic tumor.
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