No abstract

Reductive carboxylation of organo (pseudo)halides with CO 2 is ap owerfulm ethod to providec arboxylic acids quickly.Notably,the catalytic reductive carbo-carboxylation of unsaturated hydrocarbons via CO 2 fixation is ah ighly challenging but desirable approach for structurally diverse carboxylic acids.T here are only af ew reports and no examples of alkenes via transition metal catalysis.W er eport the first asymmetric reductive carbo-carboxylation of alkenes with CO 2 via nickel catalysis.Avariety of aryl (pseudo)halides,s uch as aryl bromides,a ryl triflates and inert aryl chlorides of particular note,u ndergo the reaction smoothly to give important oxindole-3-acetic acid derivatives bearing aC3-quaternary stereocenter.T his transformation features mild reaction conditions,w ide substrate scope,f acile scalability,g ood to excellent chemo-, regio-and enantioselectivities.T he method highlights the formal synthesis of (À)-Esermethole, (À)-Physostigmine and (À)-Physovenine,a nd the total synthesis of (À)-Debromoflustramide B, (À)-Debromoflustramine Ba nd (+ +)-Coixspirolactam A; thereby, opening an avenue for the total synthesis of chiral natural products with CO 2 .

Reductive carboxylation of organo (pseudo)halides with CO 2 is ap owerfulm ethod to providec arboxylic acids quickly.Notably,the catalytic reductive carbo-carboxylation of unsaturated hydrocarbons via CO 2 fixation is ah ighly challenging but desirable approach for structurally diverse carboxylic acids.T here are only af ew reports and no examples of alkenes via transition metal catalysis.W er eport the first asymmetric reductive carbo-carboxylation of alkenes with CO 2 via nickel catalysis.Avariety of aryl (pseudo)halides,s uch as aryl bromides,a ryl triflates and inert aryl chlorides of particular note,u ndergo the reaction smoothly to give important oxindole-3-acetic acid derivatives bearing aC3-quaternary stereocenter.T his transformation features mild reaction conditions,w ide substrate scope,f acile scalability,g ood to excellent chemo-, regio-and enantioselectivities.T he method highlights the formal synthesis of (À)-Esermethole, (À)-Physostigmine and (À)-Physovenine,a nd the total synthesis of (À)-Debromoflustramide B, (À)-Debromoflustramine Ba nd (+ +)-Coixspirolactam A; thereby, opening an avenue for the total synthesis of chiral natural products with CO 2 .

A protocol to prepare trans-3-aryl-2-nitro-2,3-dihydrobenzofurans has been developed on water. The protocol avoids the use of toxic solvents, tedious work-up procedures, and chromatographic separation.