Dermal fillers are applied using a minimally invasive technique with a good safety profile. However, they can have side effects. We present the case of a patient who, 2 months after undergoing polycaprolactone (Ellansé®) injections, developed nodular facial and nodal lesions that were compatible with sarcoidosis on histology. This complication has not been previously described for polycaprolactone and could be the expression of an autoimmune syndrome induced by adjuvants.
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are characterized by the presence of ANCA, particularly those directed against proteinase 3 (PR3) or myeloperoxidase (MPO). At present, the most accepted pathogenic pathway is based on the pathogenic nature of ANCA, which stimulate neutrophils with the consequent activation of the alternative complement pathway, leading to the production of C5a, an anaphylatoxin which plays a key role in amplifying the inflammatory process in AAV. Remission induction in patients with AAV continues to depend on the use of glucocorticoids (GC) in combination with rituximab or cyclophosphamide. Indeed, there are very limited treatment options and a clear need for strategies that reduce the use of GC without compromising efficacy. Avacopan is the first drug specifically developed for patients with AAV as its mechanism of action inhibits C5aR1, thus acting on one of the pathophysiological mechanisms of AAV.
Erdheim-Chester disease (ECD) is a non-Langerhans histiocytic that typically affects middle-aged adults between the fifth and seventh decades of life. It is characterized by systemic xanthogranulomatous infiltration by histiocytes CD68+/CD1a-. In this paper, we collect the main clinical characteristics of eleven patients, diagnosed with ECD at the Virgen del Rocio Hospital in Seville. After first medical contact, it has been possible to reduce the misdiagnoses and this has shortened the time to diagnosis and initiation of treatment, which has resulted in fewer complications.
Iron status and HFE mutations in first-degree relatives of patients with sporadic porphyria cutanea tarda, in a Mediterranean area
Conflict of interest statementNo conflict of interest was declared. J . S . G a r c í a -M o r i l l o , R . R a m í r e z L o r c a , M . B e r n a b e u -W i t t e l , P . S t i e f e l G a r c í a -J u n c o , E . P a m i e s A n d r e u & J . C a r n e a
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