The in situ generation of excipient fines affect bulk powder properties of DPI formulations, which directly affects fluidization and aerosolization behaviour of DPI formulations. The study suggests an alternative mode of action by which fines increase DPI formulation performance.
009ChemInform Abstract The results of 1H NMR self-diffusion experiments show that H3PO4 penetrates into the channel network of the ZSM-5 zeolite. At higher H3PO4 concentrations, an enrichment of phosphorus deposits near the external surface is observed. 27Al, 29Si, and 31P MAS NMR results show that dealumination and formation of polyphosphoric acids occurs during calcination of the H3PO4-modified zeolite. The decreased number of Broensted acid sites in the modified zeolite after heat treatment at 500 rc C is a direct result of the framework dealumination. A study of the influence of H3PO4 impregnation of H-ZSM-5 on the selective toluene disproportionation reveals a higher paraselectivity and lower catalytic activity of the modified zeolites.
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