Background To evaluate changes in pulse pressure (PP) and markers of cardiovascular autonomic neuropathy (CAN) according to duration of type 1 diabetes mellitus (T1DM).
Introduction Squatting is an active posture test that can be used to assess baroreflex sensitivity. Indeed, the shift from squatting to standing imposes a major orthostatic stress leading to rapid and large changes in arterial blood pressure (BP) and heart rate (HR) allowing precise baroreflex assessment.
Treatment with rosiglitazone increased the production of thyroglobulin in some patients with thyroid cancers, but only rarely restored scintigraphically significant iodine trapping. It remains to be shown whether longer treatment periods might result in a more efficient redifferentiating effect.
OBJECTIVE -To evaluate pulse pressure changes according to duration of type 1 diabetes and to assess the influence of posture.RESEARCH DESIGN AND METHODS -We performed continuous measurement of blood pressure with a Finapres device during a 3 ϫ 1 min posture test (standing, squatting, standing) in 159 type 1 diabetic patients divided into four groups according to diabetes duration (Յ10, 11-20, 21-30, and Ͼ30 years, groups 1-4, respectively) and compared the results with those of age-matched nondiabetic subjects.RESULTS -Pulse pressure progressively increased according to type 1 diabetes duration (P Ͻ 0.0001), especially in women, but not in age-matched nondiabetic subjects (NS). Pulsepressure increase from group 1 to group 4 was amplified in the squatting position (from 50 Ϯ 17 to 69 Ϯ 14 mmHg) compared with standing (from 44 Ϯ 15 to 55 Ϯ 12 mmHg).CONCLUSIONS -Pulse pressure increases according to type 1 diabetes duration more in women than in men, and the squatting position sensitizes such pulse-pressure increase in both sexes.
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