A circular analogue of the diffusion model adapted for continuous response tasks is applied to a continuous-outcome source memory task. In contrast to existing models of source retrieval that attribute all of the variability in responding to memory, the circular diffusion model decomposes noise into variability arising from memory and from decision processes. We compared three models: (1) a single diffusion process with trial-to-trial variability in drift rate, (2) a mixture of two diffusion processes, one with positive drift that does not vary from trial-to-trial, and a second zero-drift process that represents discrete guessing, and (3) a hybrid model that mixed positive and zero-drift processes with trial-to-trial variability in the positive drift process. Comparison of model fits to joint response error and response-time (RT) data suggest that a memory strength threshold under which no information is retrieved appears to underlie responding in a continuous-report source memory task. Additionally, we also conditioned participants' source responding on their confidence in an old/new recognition task, ruling out the possibility that participant guessing was only due to unrecognized items. Overall, our findings support an all-or-none or some-or none view of source memory retrieval and pose a challenge to continuous models of source memory.
Paper is emerging as a versatile platform for automated fluid handling with a broad range of applications in medical diagnostics and analytical chemistry. However, selectively controlling analyte transport in paper to achieve concentration or selection has been a challenge for functional analysis. Here, by combining paper-based microfluidics with acoustics, we present a rapid and powerful method to size dependently control movement of microparticles and cells in paper using surface acoustic waves (SAW). We demonstrate the unique capability of the paper-based SAW approach to trap and concentrate microparticles in paper and release them when required, achieving collection efficiency of over 98%. Given the correlation between collection efficiency, size, and applied power, the paper-based SAW approach is applied to isolate a mixture of microparticles (1.1, 3.2, and 5 μm in diameter) into different regions and also to trap and concentrate human prostate cancer PC3 cells at a predetermined site. This paper-based SAW approach provides opportunities to develop powerful and low-cost selection and analysis tools, capable of processing complex multicomponent samples, with potential applications in medical diagnostics.
The roles of minor organic layers in influencing the mechanical response of such biomineralized composites as mollusk shells and sponge spicules have been investigated. The mechanisms whereby such minor constituents govern energy dissipation in rigid biomineralized structures are discussed, and a rationale for new modes of toughening that may relate more generally to families of ceramic- or glass/organic composites is offered. New results of simple torsional tests conducted on spicule fibers of a hexactinellid sponge, Euplectella aspergillum (Euplectella a.), compared with those done on melt-drawn glass fibers, showed an enhanced ability to resist failure in torsion, whereas the glass fibers did not. This behavior was attributed to the presence of a very thin adhesive viscoelastic phase between the siliceous layers of the spicule fibers, combined with the architectural and surface features of the spicule fiber.
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