Although prednisone and prednisolone have been in use for a number of years for a wide variety of conditions, there have been few kinetic studies over the wide clinical dosage range. 5 • 9, 10, 12, 13, 15 It has been documented same subject are reproducible. 14 The conclusions from two recent studies lo , 12 in a small number of subjects given 5 to 50 mg of prednisolone or prednisone have shown that there are dose-dependent changes in the kinetics of prednisolone in man with a prolongation of half-life (t1/2)/0, 12 an increase in volume of distribution (V d)10 and plasma clearance 10,12 with increasing dose. In addition, it was noted by Meikle and TylerB that the 24-hr doseresponse to 70 mg prednisone deviated significantly from dose-response curves at lower dosages.that there is considerable interindividual variation in pharmacokinetic measurements at any single dose,4, 15 although separate studies on the Prednisone has very little intrinsic glucocorticoid activity I and has to be converted to pred-0009-9236/79/050571+08$00.80/0
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